PMID: 15362497Sep 15, 2004Paper

Biochemical effects of Citrullus colocynthis in normal and diabetic rats

Molecular and Cellular Biochemistry
Fatma Al-GhaithiMohamed H Amiri

Abstract

Diabetes mellitus is one of the most common endocrine diseases. In UAE many traditional plants such as the Citrullus colocynthis (Handal) are used as antidiabetic remedies. The aim of this study was to examine the effect of the aqueous extract of the seed of C. colocynthis on the biochemical parameters of normal and streptozotocin (STZ)-induced diabetic rats. Diabetes mellitus was induced by a single intraperitoneal (60 mg/kg body wt1) injection of STZ. Normal and diabetic rats were fed with the plant extract daily by oral intubation for 2 weeks. Blood sample were collected at the beginning and end of the experiment for the measurement of biochemical parameters. The plasma level of alanine aminotranferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), lactic dehydrogenase (LDH) increased significantly after the onset of diabetes. Oral administration of the plant extract reduced the plasma level of AST and LDH significantly. However, the plant extract failed to reduce the increased blood level of GGT and ALP in diabetic rats. Blood urea nitrogen (BUN) increased significantly after the onset of diabetes. No significant difference was observed in the blood creatinine, K+, Na+...Continue Reading

Citations

Aug 15, 2007·Pakistan Journal of Biological Sciences : PJBS·Walid Sh QazanHaytham Daradka
Aug 15, 2007·Pakistan Journal of Biological Sciences : PJBS·Haytham DaradkaOmar H Samara
Feb 7, 2014·Pakistan Journal of Biological Sciences : PJBS·Ali Akbar RashidiParisa Sarkhail
Jun 19, 2020·Journal of Diabetes and Metabolic Disorders·Akram AhangarpourLeila Yazdanpanah
Sep 29, 2011·Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional·M Nadeem AsgharN Bano
Aug 9, 2018·Frontiers in Pharmacology·Khafsa MalikSyed N Shah
Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Musa Mumammad AliyuMagaji Garba Mohammed
Oct 29, 2010·Pharmaceutical Biology·Amal Al-Aboudi, Fatma U Afifi

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