PMID: 38360Jun 15, 1979

Biochemical effects of psychotropic drugs in central nervous system (author's transl)

Klinische Wochenschrift
M Karobath

Abstract

Studies on the biochemical effects of clinically used psychotropic drugs in brain have shown that they all exert their action by a direct or indirect interference with synaptic transmission. Thus, animal studies in vivo and in vitro have shown that the clinical efficacy of antipsychotic drugs correlates with their inhibitory action on dopamine receptors. In vivo these compounds enhance dopamine turnover in the brain and in vitro they inhibit the dopamine sensitive adenylate cyclase and the binding of dopamine to its receptor at neuronal membranes. Tricyclic antidepressants are drugs which have effects on many transmitter systems. No specific biochemical action has been found which is closely correlated with their clinical potency. However, it appears that a stimulation of the function of the noradrenergic system might have some clinical relevance. Benzodiazepines exert their pharmacological activity in the CNS by interacting with a brain specific receptor. This receptor appears to be part of a larger complex including a GABA receptor and the chloride conductance mechanism associated with the GABA receptor. By binding to their receptor, benzodiazepines appear to enhance the sensitivity of the GABA receptor, thus indirectly poten...Continue Reading

Citations

Jul 27, 1978·Nature·J F TallmanD W Gallager
Jan 1, 1976·International Pharmacopsychiatry·D Luchins
Sep 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·W E Haefely
Sep 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·E CostaG Toffano
Sep 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·H Möhler, T Okada
Sep 1, 1975·Archives of General Psychiatry·R J Baldessarini
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M E Karobath, G Sperk
Mar 23, 1978·Nature·P D Kanof, P Greengard
Sep 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·C Braestrup, R F Squires
Oct 1, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·K StarkeG HERTTING
Sep 1, 1977·Biochemical Pharmacology·M RehaviM Sokolovsky
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·D R BurtS H Snyder
Jan 1, 1975·Annual Review of Medicine·S Matthysse, J Lipinski
Jul 1, 1975·Pharmakopsychiatrie, Neuro-Psychopharmakologie·M E Karobath
Feb 1, 1976·The American Journal of Psychiatry·S H Snyder
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·Y C Clement-CormierP Greengard
Jan 1, 1972·Journal of Neural Transmission·A CarlssonJ Wålinder
Jan 1, 1973·Annual Review of Physiology·R J Baldessarini, M Karobath
Jul 4, 1973·Psychopharmacologia·B AngristS Gershon

Related Concepts

Exertion
Tissue Membrane
Sympathetic Nervous System
Neurosteroids
Brain
Synaptic Transmission
Entire Central Nervous System
Norepinephrine, (+, -)-Isomer
Gammalon
GABA Receptor

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