Biochemical effects of vepacide (from Azadirachta indica) on Wistar rats during subchronic exposure

Ecotoxicology and Environmental Safety
M F Rahman, M K J Siddiqui

Abstract

We investigated the effect of Vepacide (from Azadirachta indica), a neem-based pesticide, on acid (AcP) and alkaline (AkP) phosphatase in different tissues of male and female albino Wistar rats. Subchronic doses of Vepacide in coconut oil (80, 160, and 320 mg/kg; maximum volume of 0.2 mL) were administered orally for 45 or 90 days. The administration of Vepacide resulted in a significant increase in AcP and AkP in serum, kidney, lung, and liver tissue (AkP only in liver), whereas a significant decrease of AcP in liver was observed in male and female rats after 45 and 90 days of treatment with moderate and high doses. The alterations in serum, liver, kidney, and lung tissues of both male and female rats caused by this compound were statistically significant, and the changes were also dose and time dependent. The alterations in male rats were not statistically significant when compared with female rats, indicating that there were no sexual differences. The withdrawal study (28 days post-treatment) revealed significant recovery, indicating reversal of the toxic symptoms once the toxicant was removed. There was a high degree of positive correlation between results for serum as compared to those for kidney, lung, and liver (AkP only...Continue Reading

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Citations

Feb 11, 2014·Pakistan Journal of Biological Sciences : PJBS·Shori Amal Bakr
Sep 26, 2015·Environmental Science and Pollution Research International·Hoda M NasrWael A El-Nagar
Jul 20, 2011·Fish & Shellfish Immunology·Xiwei JiaZiping Zhang
Jun 9, 2009·Ecotoxicology and Environmental Safety·Sengottayan Senthil-NathanKandaswamy Kalaivani
Feb 6, 2017·Fish & Shellfish Immunology·Jinfen WeiDahui Yu
Jul 11, 2018·Arhiv za higijenu rada i toksikologiju·Vedran Mužinić, Davor Želježić
Dec 20, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ryoko YumotoMikihisa Takano
Feb 13, 2018·Experimental and Therapeutic Medicine·Jin-Bo ZhangLing-Ling Dai
Jan 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Teresa M BragaAgostinho Cruz

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