Biochemical interaction of six OP delayed neurotoxicants with several neurotargets

Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
A H el-SebaeA Curley

Abstract

Five organophosphorous insecticides: Leptophos, EPN, Cyanofenphos, trichloronate and salithion proved to cause irreversible ataxia not only to chicken but also to mice and sheep. TOCP was included as a reference. Cyanofenphos blocked the catecholamine B-receptor binding activity with 3H-norepinephrine at a level similar to that of the specific inhibitor propranolol in the mouse heart preparation. In the lamb heart preparation, the B-receptor was more sensitive to Leptophos, salithion and TOCP than to propranolol. The six compounds and their oxons were screened for their in-vitro inhibition to monamine oxidase (MAO), acetyl cholinesterase (AChE) and neurotoxic esterase (NTE) in the brain of either mouse, lamb or chicken. It is believed that their AChE inhibition stands for their acute toxicity, while NTE inhibition is responsible for their paralytic ataxia.

References

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Citations

Jan 1, 1984·Psychopharmacology·R Bose, C Pinsky
Jan 1, 1984·Pharmacology, Biochemistry, and Behavior·C Pinsky, R Bose
Jan 1, 1984·Pharmacology, Biochemistry, and Behavior·F S Messiha
Nov 1, 1991·Biological Trace Element Research·A GhoshG Talukder
Jan 1, 1991·Critical Reviews in Toxicology·M Lotti
May 1, 2005·Environmental Toxicology and Pharmacology·Carey PopeJing Liu
Jul 14, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Elizabeth UndianoAntonio Monroy-Noyola

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