PMID: 6168368Jul 15, 1981Paper

Biochemical markers in the plasma and tumors of patients with gynecologic malignancies

Cancer
J R van NagellE J Pavlik

Abstract

Tumor markers in gynecologic malignancies can be classified generally as oncofetal proteins, carcino-placental proteins, and more specific tumor-associated antigens. Carcinoembryonic antigen (CEA) is most effective as a tumor marker in mucinous adenocarcinomas of the endocervix and ovary and in keratinizing squamous cell carcinomas of the cervix. In contrast, the use of alphafetoprotein (AFP) in gynecologic cancer is limited to patients with germ cell tumors of the ovary and specifically endodermal sinus tumors. The beta subunit of human chorionic gonadotropin (beta-hCG) remains an exemplary tumor marker for trophoblastic malignancies and may be useful in selected patients with epithelial carcinomas of the ovary. Plasma levels of these antigens are generally related to total tumor burden (tumor antigen concentration x extent of disease)). Although the lack of specificity of these markers has limited their use in the diagnosis of gynecologic malignancies, they have been effective as a means of monitoring disease status in patients whose tumors contain high antigen concentrations. More specific tumor-associated antigens have been described in ovarian cervical cancers, but their clinical efficacy remains to be demonstrated in larg...Continue Reading

References

Jun 15, 1976·American Journal of Obstetrics and Gynecology·R M BurtonL M Lubbers
Nov 15, 1976·International Journal of Cancer. Journal International Du Cancer·A SellB Norgaard-Pedersen
May 15, 1978·International Journal of Cancer. Journal International Du Cancer·N ImamuraL J Old
Sep 1, 1978·Cancer·M Bhattacharya, J J Barlow
Dec 1, 1979·Gynecologic Oncology·C R StanhopeP K Crosley
Jan 15, 1975·American Journal of Obstetrics and Gynecology·P J DiSaiaC P Morrow
Jul 1, 1976·Cancer·D P Goldstein
Sep 1, 1978·Cancer·F J PrimusD M Goldenberg
Oct 15, 1979·American Journal of Obstetrics and Gynecology·H GallionM Hanson
May 1, 1978·Obstetrics and Gynecology·K E Kjorstad, H Orjaseter
Jan 1, 1975·Annals of Internal Medicine
Jun 1, 1977·American Journal of Obstetrics and Gynecology·J R van NagellD M Goldenberg
Apr 1, 1975·American Journal of Obstetrics and Gynecology·J R JonesG I Solish
Sep 1, 1975·Journal of Immunological Methods·F J PrimusD M Goldenberg
Jan 1, 1971·Advances in Cancer Research·G I Abelev
Jul 1, 1973·American Journal of Obstetrics and Gynecology·E J WilkinsonT A Hosty
Nov 15, 1973·American Journal of Obstetrics and Gynecology·M Bhattacharya, J J Barlow
Aug 1, 1974·American Journal of Obstetrics and Gynecology·S Knauf, G I Urbach
Sep 15, 1967·International Journal of Cancer. Journal International Du Cancer·G I AbelevN I Perevodchikova
Nov 15, 1969·American Journal of Obstetrics and Gynecology·M M LeviI Mandl
Oct 2, 1969·The New England Journal of Medicine·L L StolbachW H Fishman
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P K Nakane, A Kawaoi
Feb 1, 1973·The Australian & New Zealand Journal of Obstetrics & Gynaecology·S K Khoo, E V Mackay
Apr 17, 1972·JAMA : the Journal of the American Medical Association·G ReynosoG P Murphy
Feb 1, 1973·American Journal of Obstetrics and Gynecology·S A GallJ Pearl
Jul 15, 1972·American Journal of Obstetrics and Gynecology·J L VaitukaitisG T Ross

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Citations

Oct 1, 1983·Gynecologic Oncology·J H MeerwaldtM E v d Burg
Apr 20, 2012·Immunotherapy·David A Christian, Christopher A Hunter
Jan 1, 1990·Archives of Gynecology and Obstetrics·D L van KranenburgE K Pauwels
Dec 1, 1993·British Journal of Obstetrics and Gynaecology·C K Bose, M Mukherjea
Mar 1, 1984·Medical Hypotheses·G Umbach
Nov 1, 1989·European Journal of Cancer & Clinical Oncology·W MeierH Hepp
Jul 2, 1998·Gynecologic Oncology·M TakemoriK Hasegawa
May 1, 1985·The Histochemical Journal·J O DaviesC A Sunderland
Jun 1, 1987·Asia-Oceania Journal of Obstetrics and Gynaecology·K C ChaoC M Chang
Nov 1, 1985·Journal of the Royal Society of Medicine·J O DaviesC A Sunderland
Jan 16, 2020·Annals of Coloproctology·Claire HallFrank Frizelle

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