Biochemical markers of endothelial activation in primary hyperparathyroidism

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
F FalloF Lumachi

Abstract

Patients with primary hyperparathyroidism (PHPT) have impaired vasodilation both dependent and independent of endothelium. The aims of our study were to measure three different biochemical markers of endothelial activation, i. e., plasma thrombomodulin, soluble(s) E-selectin, and von Willebrand factor, in PHPT patients before and one year after successful parathyroidectomy, and to distinguish the potential effect of hypercalcemia and/or high parathyroid hormone from that of major cardiovascular risk factors (diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking habit) on endothelial function. Twenty consecutive patients with PHPT subdivided into two groups according to the absence (n = 8) or presence (n = 12) of one or more risk factors, and fifteen healthy normocalcemic subjects were studied. Baseline thrombomodulin levels were similar in the groups with and without risk factors, and in controls. In contrast, sE-selectin and von Willebrand factor were higher in PHPT patients with risk factors than in those without risk factors (p < 0.05 and p < 0.01, respectively) and controls (p < 0.01). Neither thrombomodulin nor sE-selectin changed after parathyroidectomy in either PHPT group. Plasma von Willebrand factor decrea...Continue Reading

Citations

Sep 10, 2008·Current Osteoporosis Reports·Lorraine A FitzpatrickShonni J Silverberg
Nov 26, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jan RosaJiri Widimsky
Nov 4, 2010·Clinical Endocrinology·Anita PerssonUNKNOWN SIPH Study Group
Apr 9, 2009·The Journal of Clinical Endocrinology and Metabolism·Jens BollerslevUNKNOWN SIPH Study Group

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