Biochemical markers of glucose metabolism may be used to estimate the degree and progression of iron overload in the liver and pancreas of patients with β-thalassemia major

Annals of Hematology
Munevver BasSule Unal

Abstract

The use of cardiac and hepatic T2* MRI measurements to predict the amount of iron accumulation in these organs has been studied extensively and was suggested to be used reliably. However, it may not be practical to screen other organs with MRI related to economical issues and also the prolonged imaging durations. Herein, we aimed to test the use of fasting glucose, fasting, and postprandial insulin, homeostasis model assessment-insulin resistance (HOMA-IR) (calculated as insulin (μIU/ml) × glucose (mg/dl)/22.5), and homeostasis model assessment B score (HOMA-B) (calculated as insulin (μIU/ml) × 20/glucose (mg/dl) - 3.5) to estimate the tissue iron measured with MRI. A total of 37 patients with β-thalassemia major (BTM), age 20.8 ± 6.3 years (7.1-36.8), were enrolled. MRI measurements were done concomitantly to the biochemical tests for glucose metabolism. A positive correlation between HOMA-IR and hepatic iron loading and a negative correlation between pancreatic T2* and fasting blood glucose were found. A positive correlation was found between fasting insulin levels and pancreatic R2* measures. Additionally, a correlation was detected between cardiac and pancreatic iron accumulations. In centers where T2*/R2* MRI facilities ar...Continue Reading

References

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Citations

Dec 25, 2015·Expert Review of Hematology·Vincenzo De SanctisMohamed Yassin
Oct 16, 2015·Expert Review of Hematology·Raffaella OrigaCaterina Borgna-Pignatti
Dec 12, 2017·Journal of Pediatric Hematology/oncology·Arif M AnsariNitin Joseph
May 4, 2020·Journal of Ethnopharmacology·Rhanany Alan Calloi PaloziArquimedes Gasparotto Junior

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