Biochemical Markers of Oxidative Stress in Saudi Women with Recurrent Miscarriage

Journal of Korean Medical Science
Hazem K Ghneim, Mashael M Alshebly

Abstract

This study was undertaken to investigate the antioxidant/oxidant status in recurrent miscarriage patients. Antioxidants including glutathione peroxidase (GPx), catalase (CAT), glutathione reductase (GR), reduced glutathione (GSH) and selenium (Se), as well as the oxidants hydrogen peroxide (H2O2), oxidised glutathione (GSSG) and lipid peroxidation were assayed in plasma, whole blood and placental tissue of non-pregnant women (NP), healthy pregnant women (HP), and recurrent miscarriage (RM) patients. Results indicated that all antioxidant activities and levels in plasma and whole blood of HP women were consistently moderately lower, and much more significantly lower in RM patients when both were compared to those seen in NP women (P<0.05 and P<0.001, respectively). Furthermore, whereas plasma antioxidant activities and levels were significantly lower in RM patients, those of whole blood and placental tissue were much more significantly lower when compared with HP women (P<0.001). Concurrent with these findings there were consistent increases of equal statistical significance and magnitude in the levels of all investigated oxidants assayed in all samples when compared in between subjects of the study as indicated above. Data thus...Continue Reading

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Citations

Apr 15, 2017·Genetic Testing and Molecular Biomarkers·Valentina BrunoFrancesca Amati
Mar 2, 2018·American Journal of Reproductive Immunology : AJRI·Hui-Li YangMing-Qing Li
Jan 29, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Letícia Bigolin JantschThissiane de Lima Gonçalves
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Jul 5, 2017·Experimental and Therapeutic Medicine·Yazeed A Al-SheikhMourad A M Aboul-Soud
Feb 3, 2021·Zeitschrift für Geburtshilfe und Neonatologie·Taylan OnatEthem Serdar Yalvac
Dec 22, 2019·The Science of the Total Environment·Rajinder ChawlaMarco Vinceti
Aug 17, 2021·Frontiers in Medicine·Nourah H Al QahtaniJ Francis Borgio

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Methods Mentioned

BETA
MDA

Software Mentioned

SPSS
Aebi

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