Biochemical maturation of the non-innervated chick optic lobe

Developmental Neuroscience
S C BondyC York


The development of the chick optic lobe was impaired following removal of the optic cup of the early embryo. Tectal cell number is reduced but cell size may be relatively normal. Ther was evidence of neuronal cell death and several neuron-associated proteins and enzymes (nerve-specific protein and acetylcholinesterase) showed selectively impaired maturation. However, other nerve-specific enzymes (choline acetyltransferase, tyrosine hydroxylase), develop normally on a per cell basis. The noninnervated optic lobe had a normal blood-brain barrier but a depressed ability to accumulate amino acids from plasma. Levels of 3':5'-cyclic GMP were also reduced in the nonafferented lobe.


Sep 1, 1978·Brain Research Bulletin·S C BondyC L Anderson
Feb 1, 1982·Neurochemical Research·S C BondyA K Agrawal
Oct 15, 1989·The Journal of Comparative Neurology·P BagnoliL Sebastiani

Related Concepts

Cyclic AMP, (R)-Isomer
Chick Embryo
Choline O-Acetyltransferase
Optic Lobe, Nonmammalian
Cyclic GMP
Tyrosine 3-Monooxygenase
Nerve Tissue Proteins

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