Biochemical measurements of glucose metabolism in relation to cause of death and postmortem effects

Zeitschrift für Rechtsmedizin. Journal of legal medicine
G KernbachB Brinkmann

Abstract

This study was performed to examine the relationship between postmortem biochemical values and cause of death. The follow samples were taken from 399 corpses: cerebrospinal fluid (CSF; n = 376, suboccipital), blood (n = 158, femoral vein), and urine (n = 101, at autopsy). (See Table 1 for causes of death) All samples were stored at -80 degrees C. A further 100 samples of blood were later taken and stored at +4 degrees C before testing. Biochemical determinations made were: glucose in CSF, blood, and urine (hexokinase method); lactate (LDH/GPT) and free acetone (HS-gas chromatography) in CSF; hemoglobin A1 in blood (microcolumn technique). In 34 cases fatal diabetic coma was considered verified by morphological and chemical findings. One hundred cases of sudden cardiac death were chosen as the main control group. In 32 of the 34 cases defined above, the value of the formula of Traub (glucose + lactate in CSF) exceeded 415 mg/dl. It is not influenced significantly by hyperglycemia or hyperlactatemia due to factors other than diabetes (i.e., carbon monoxide, asphyxia). After death the value rose till the 30th hpm, then remained stable for at least 1 week. Fatal coma was defined as the ketoacidotic form if free acetone in CSF range...Continue Reading

Citations

Oct 12, 2010·International Journal of Legal Medicine·Frank MusshoffBurkhard Madea
Sep 29, 2011·International Journal of Legal Medicine·Cristian Palmiere, Patrice Mangin
Oct 5, 2013·International Journal of Legal Medicine·Terhi KeltanenKatarina Lindroos
Sep 30, 2010·International Journal of Legal Medicine·Cornelius HessBurkhard Madea

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