Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice.

Digestive Diseases and Sciences
Debashish BanerjeeSubrata Chattopadhyay

Abstract

Indomethacin caused maximum stomach ulceration in mice on the 3rd day, which was associated with reduction of plasma total antioxidant status (TAS), COX-1, COX-2, mucosal PGE(2), VEGF, and vWF, along with an increase in endostatin levels. Treatment with the phytochemical allylpyrocatechol (5 mg/kg, p.o. for 3 days) provided significant ulcer healing by reversing these biochemical parameters, as well as increasing the EGF expression more than that observed due to ulceration. Omeprazole (3 mg/kg, p.o. for 3 days) provided a similar healing by improving TAS and mucin levels, without significantly altering the other parameters.

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Citations

Nov 17, 2015·Journal of Ethnopharmacology·María Filomena GarroAlejandra Olivia Maria
May 30, 2009·Free Radical Research·Ali SolmazBerrak C Yeğen
Jun 16, 2015·World Journal of Gastroenterology : WJG·Mohammad Hosein FarzaeiRoja Rahimi
Oct 7, 2020·Clinical and Experimental Pharmacology & Physiology·Gisele Maziero AlvesBianca Prandi Campagnaro
Aug 25, 2020·ACS Chemical Neuroscience·Rehab E Abo El GheitMarwa N Emam

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