PMID: 41800Jan 1, 1979

Biochemical mechanism of nitrofurantoin resistance in Vibrio el tor

Folia Microbiologica
P Ghosh DastidarG C Chatterjee

Abstract

Vibrio el tor cells contain a constitutive reductase enzyme which converts nitrofurantoin to an active principle that is responsible for the observed antibacterial activity of the drug. Acquisition of resistance of this strain towards nitrofurantoin is associated with the loss of this reductase. This enzyme is located in the periplasmic region of the nitrofurantoin-sensitive cells, and seems to play an important role in transporting the drug into the cells.

References

Jan 1, 1983·Folia Microbiologica·S HaldarG C Chatterjee
Jan 1, 1982·Critical Reviews in Clinical Laboratory Sciences·R E Brown, D T Forman
Jan 4, 2019·Nature·François-Xavier WeillMarie-Laure Quilici

Citations

Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P Herrlich, M Schweiger
Jan 1, 1973·Annual Review of Biochemistry·R Benveniste, J Davies
Oct 1, 1968·Biochemical Pharmacology·M T Umar, M Mitchard
Dec 28, 1964·Annals of the New York Academy of Sciences·B J DAVIS
Dec 1, 1970·Journal of Bacteriology·D R McCallaC Kaiser
Sep 23, 1949·Science·G N SmithB L Lilligren

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Antibiotic Resistance, Microbial
Vibrio cholerae
Macrodantin
Sodium Chloride, (24)NaCl
Hydrogen-Ion Concentration

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