Biochemical post-mortem findings in depressed patients.

Journal of Neural Transmission
W Birkmayer, P Riederer

Abstract

Biochemical human post-mortem studies on depressed patients indicate an unspecific deficiency of neurotransmitters in several brain areas. The loss of drive of these patients could be correlated with a decrease of striatal dopamine concentration. Noradrenaline was significantly diminished in red nucleus, a fact which points to the characteristic posture of depressed patients. Serotonin was diminished in all brain areas. During remission all values trended to be normal. There also exists a circadian disrhythm in depressed patients resulting in lowered VMA- and HVA-levels in urines during the morning and a remission to normal values in the evening. This agrees with the findings of lowered blood tyrosine levels in the morning. The ratio of blood tyrosine and tryptophan is disturbed during depression and recovers during remission. Central and peripheral biochemical mechanisms seems to be involved in depression syndrom.

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Citations

Jan 1, 1985·Journal of Neural Transmission·O S Jørgensen, P Riederer
Jan 15, 1988·Biological Psychiatry·E R KorpiR J Wyatt
Jul 1, 1995·Biological Psychiatry·R J WyattM F Casanova
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Aug 1, 1989·Psychiatry Research·R RupprechtP Riederer
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Jan 31, 2017·The Journal of Pharmacy and Pharmacology·Gerard EstebanMercedes Unzeta
Jan 1, 1987·Nutrition and Health·D N Challacombe, E E Wheeler
Oct 1, 1986·Klinische Wochenschrift·C Schlagmann, J Remien
Mar 1, 1988·The Australian and New Zealand Journal of Psychiatry·B Boman
Jan 1, 1986·Suicide & Life-threatening Behavior·H M van Praag
Aug 1, 1988·Annals of Neurology·R M ZweigD L Price

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