PMID: 10602Nov 1, 1976Paper

Biochemical properties of the prostaglandin/thromboxane synthetase of human blood platelets and comparison with the synthetase of bovine seminal vesicles

Prostaglandins
H L White, A T Glassman

Abstract

The enzyme system which synthesizes prostaglandins and thromboxanes in extracts of washed human platelets has been characterized with respect to kinetic parameters, pH and cofactor dependence, and inhibitor potencies. Arachidonate and dihomo-gamma-linolenate were shown to be mutually competitive substrates, thus providing biochemical support for the assumption that both substrates are metabolized by the same cyclooxygenase, although they are ultimately metabolized to different patterns of products. Products of the synthetase of human leucocytes qualitatively resemble those obtained with human platelets. The prostaglandin synthetase of bovine seminal vesicles was studied under similar conditions, and kinetic parameters and inhibitor potencies were compared with those of platelet extracts.

References

Jan 26, 1976·Biochemical and Biophysical Research Communications·C MalmstenB Samuelsson
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Feb 23, 1976·Biochimica Et Biophysica Acta·T K BillsM J Silver
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M Hamberg, B Samuelsson
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·T MiyamotoO Hayaishi
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M Hamberg, B Samuelsson
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Apr 1, 1972·The Biochemical Journal·W J McDonald-GibsonM W Greaves
Oct 1, 1972·Prostaglandins·W J McDonald-GibsonM W Greaves
Feb 25, 1974·Prostaglandins·N W Schoene, J M Iacono
Jan 10, 1974·Prostaglandins·A L Willis
Jul 25, 1974·Prostaglandins·H L White, A T Glassman

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Citations

Jun 1, 1980·Molecular and Cellular Endocrinology·A Duperray, E M Chambaz
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S Hammarström, P Falardeau
Dec 22, 1978·Biochimica Et Biophysica Acta·H H Tai, B Yuan
Jun 27, 1979·Biochemical and Biophysical Research Communications·M Lagarde
Oct 1, 1977·Thrombosis Research·M AliJ W McDonald
Mar 1, 1979·Prostaglandins and Medicine·R L Tansik, H L White
Feb 1, 1980·Thrombosis Research·M LagardeM Dechavanne
Nov 1, 1982·Circulation Research·E F EllisH A Kontos
Aug 14, 1982·British Medical Journal

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