Abstract
The aim of this study was to characterize the time-resolved progression of clinical laboratory disturbances days-following an exertional heat stroke (EHS). Currently, normalization of organ injury clinical biomarker values is the primary indicator of EHS recovery. However, an archetypical biochemical recovery profile following EHS has not been established. We performed a retrospective analysis of EHS patient records in US military personnel from 2008-2014 using the Military Health System Data Repository (MDR). We focused on commonly reported clinical laboratory analytes measured on the day of injury and all proceeding follow-up visits. Over the prescribed period, there were 2,529 EHS episodes treated at 250 unique treatment locations. Laboratory results, including a standardized set of blood, serum and urine assays, were analyzed from 0-340 days following the initial injury. Indicators of acute kidney injury, including serum electrolyte disturbances and abnormal urinalysis findings, were most prevalent on the day of the injury but normalized within 24-48hours (creatinine, blood urea nitrogen, and blood and protein in urine). Muscle damage and liver function-associated markers peaked 0-4 days after injury and persisted outside t...Continue Reading
References
Jul 13, 1979·JAMA : the Journal of the American Medical Association·P G Hanson, S W Zimmerman
Jun 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R W HubbardJ W Ratteree
Mar 1, 1992·The International Journal of Biochemistry·A van der LindeS E Terblanche
Feb 1, 1990·Medicine and Science in Sports and Exercise·L E ArmstrongR W Hubbard
Aug 1, 1970·The American Journal of Medicine·M KewG Kent
Jan 1, 1971·Transactions of the Royal Society of Tropical Medicine and Hygiene·M KewH Seftel
Nov 1, 1966·The Journal of Clinical Investigation·L B RowellF Kusumi
Aug 9, 1980·Lancet·M Khogali, J S Weiner
Jan 1, 1983·European Journal of Applied Physiology and Occupational Physiology·T D NoakesJ Dykman
May 1, 1982·Medicine·P A GabowS P Kelleher
Nov 1, 1993·Chest·A BouchamaM Rezeig
Jul 10, 2001·Journal of Digital Imaging·M R Ogiela, R Tadeusiewicz
Aug 31, 2001·Medicine and Science in Sports and Exercise·L T PhinneyC B Wenger
Aug 13, 2002·American Journal of Physical Medicine & Rehabilitation·Henry L LewIrina Melnik
Apr 15, 2004·Military Medicine·Shilpa HakreC Bruce Wenger
Aug 25, 2005·Medicine and Science in Sports and Exercise·Robert CarterPaul J Amoroso
Mar 27, 2007·Emergency Medicine Journal : EMJ·Young Soon ChoSeung Ho Kim
Oct 10, 2007·Journal of Sport Rehabilitation·Brendon P McDermottCarl M Maresh
May 1, 2009·Military Medicine·Pasiri SithinamsuwanUNKNOWN Phramongkutklao Army Hospital Exertional Heatstroke Study Team
Sep 10, 2010·Current Sports Medicine Reports·Francis G O'ConnorMichael Sawka
May 17, 2011·European Journal of Internal Medicine·Lior ZellerYaniv Almog
Mar 7, 2014·Military Medicine·Amandine AbriatEmmanuel Sagui
Jul 2, 2014·Medicine and Science in Sports and Exercise·Julie K DemartiniJohn Jardine
Mar 11, 2015·Annals of Family Medicine·Carlos JacksonC Annette DuBard
Mar 31, 2015·Journal of Applied Physiology·Michelle A KingThomas L Clanton
Sep 19, 2015·Journal of Athletic Training·Douglas J CasaSusan W Yeargin
Feb 21, 2016·Sports Health·Chad A Asplund, Francis G O'Connor
Jun 9, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Glenn T Nagami
Jan 17, 2017·Current Sports Medicine Reports·Rebecca L StearnsRebecca M Lopez
Jul 7, 2017·World Journal of Emergency Medicine·Jeffrey GardeckiAlan Lucerna
Citations
Jul 8, 2020·Hospital Practice·Charat ThongprayoonWisit Kaewput
May 10, 2020·Journal of Clinical Medicine·Tarun BathiniWisit Kaewput
Oct 1, 2020·International Journal of Environmental Research and Public Health·Faith O AleleMelissa J Crowe
Dec 30, 2020·Medicina·Rebecca L StearnsDouglas J Casa
Dec 9, 2020·Journal of Athletic Training·Kevin C MillerM Seth Smith
Jun 8, 2021·Frontiers in Medicine·Ming WuZhifeng Liu
Sep 17, 2021·Journal of Applied Physiology·Aaron R CaldwellLisa R Leon