Biochemical responses and accumulation properties of long-chain perfluorinated compounds (PFOS/PFDA/PFOA) in juvenile chickens (Gallus gallus)

Archives of Environmental Contamination and Toxicology
Leo W Y YeungPaul K S Lam

Abstract

One-day-old male chickens were exposed via oral gavage to mixtures of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorodecanoate (PFDA) at either a low dose (0.1 mg/kg body weight [b.w.]) or a high dose (1.0 mg/kg b.w.), or a saline/ethanol vehicle control, three times a week for 3 weeks. After 3 weeks of exposure, half of the chicks were sacrificed and the other half were allowed to depurate for a further 3 weeks. No dose-dependent statistically significant differences in body/organ weights were observed among treatment and control groups after 3 weeks of exposure or after three 3 of depuration. Neither 15 histological nor 14 measured plasma biochemical parameters were significantly different in chicks from the exposed groups and vehicle controls. PFOS, PFDA, and PFOA concentrations in blood/liver/kidney samples were measured throughout the exposure and depuration periods at different time intervals. PFOS and PFDA accumulated at much higher concentrations than PFOA during the experimental periods. Interestingly, PFOS and PFDA accumulation patterns in the blood were similar during the exposure and depuration periods. The half-lives for each PFC at the 0.1 and 1.0 mg/kg doses were, respectively, approxim...Continue Reading

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Citations

Mar 29, 2012·Archives of Environmental Contamination and Toxicology·Janine KowalczykMonika Lahrssen-Wiederholt
Jun 26, 2013·Food Chemistry·E D van AsseltH J van der Fels-Klerx
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Oct 27, 2018·Environmental Science & Technology·Jinghua WangJiayin Dai
Jan 20, 2011·Environmental Science & Technology·Lutz AhrensRalf Ebinghaus

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