PMID: 11920899Mar 29, 2002Paper

Biochemical screening for Down syndrome in pregnancies following renal transplantation

Prenatal Diagnosis
C N KaridasD L Economides

Abstract

To assess the performance of the double marker test [free beta-human chorionic gonadotrophin (beta-hCG) and alpha-fetoprotein (AFP)] as a screening test for Down syndrome in pregnant patients who had a prior renal transplant. A retrospective study. The Fetal Medicine Unit, Royal Free Hospital, London, UK. Detailed records of 14 post-renal transplant pregnancies were obtained from the Renal Unit of our hospital where the patients were followed up. The serum concentrations of urea, creatinine, free beta-hCG and AFP at the time of the double marker test were recorded, with a cut-off point of 1:250 for the double marker test. A control group of 14 normal pregnancies matched for age, parity and gestational age was used. The Mann-Whitney U-test and t-tests of unequal variance were applied to compare parameters of the study and the control groups. Two patients in each group were high risk for Down syndrome and amniocentesis revealed normal karyotype. No babies with Down syndrome were delivered in either group. Regression analysis showed significant correlation between free beta-hCG and urea concentrations (p<0.001) and free beta-hCG and creatinine concentrations (p<0.001), but not for AFP. The present study demonstrates that residual ...Continue Reading

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Citations

Jul 13, 2002·Prenatal Diagnosis
Jun 7, 2006·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·L M Byrd, P Baker
Aug 12, 2009·Prenatal Diagnosis·Kevin SpencerAnastasia Stamatopoulou
Nov 15, 2014·Prenatal Diagnosis·Morgane ValentinLaurent J Salomon
Feb 20, 2003·American Journal of Obstetrics and Gynecology·Chui Miu LamKai Ming Chow
Apr 27, 2010·American Journal of Obstetrics and Gynecology·Alexandra BenachiFrançoise Muller
Jan 25, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Adam MortonTony Prado

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