Biochemical Screening for Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia

Neonatology
Angela M MontgomeryConstance G Weismann

Abstract

Pulmonary hypertension (PH) in infants with bronchopulmonary dysplasia (BPD) is associated with increased morbidity and mortality. Elevated levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and decreased levels of amino acid precursors of nitric oxide (NO) have been associated with PH, but have not been studied in infants with PH secondary to BPD. The aim of this study was to identify a biochemical marker for PH in infants with BPD. Twenty infants, born at <27 weeks' gestational age (GA) and/or with a birth weight (BW) ≤750 g, who met the criteria for BPD at 36 weeks' corrected GA (CGA) were enrolled in this cross-sectional pilot study. A screening echocardiogram was conducted at 36-38 weeks' CGA and plasma NT-proBNP and amino acid levels were obtained within 1 week of the screening echocardiogram. Five infants (25%) had echocardiographic evidence of PH. GA and BW were not significantly different between the 2 groups (a PH group and a No PH group). NT-proBNP was significantly elevated in the PH group (median 1,650 vs. 520 pg/ml; p = 0.001) but citrulline levels were significantly lower (median 21 vs. 36 μmol/l; p = 0.005). Arginine levels were not significantly different between the groups (median 78 vs. 79 μmol/l...Continue Reading

Citations

Feb 17, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·C G WeismannM J Bizzarro
Nov 29, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·Gautham SureshSunil K Jain
Oct 21, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kai KönigDan M Casalaz
Jan 23, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sanne ArjaansSteven H Abman
Jan 12, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Tao XiongMohan Pammi
Mar 2, 2019·European Journal of Pediatrics·Paula Méndez-AbadIsabel Benavente-Fernández
Oct 4, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·David E Surate SolaligueRory E Morty
Jan 9, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Buria NaeemSunil K Jain
Jul 7, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Soham DasguptaSunil K Jain
Jun 14, 2018·Pediatric Research·Martina A SteurerLaura L Jelliffe-Pawlowski
Jun 11, 2020·Pediatric Research·Georg HansmannUNKNOWN European Pediatric Pulmonary Vascular Disease Network (EPPVDN)
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Fiammetta PiersigilliVineet Bhandari
May 28, 2020·Frontiers in Pediatrics·Ahmed El-Saie, Binoy Shivanna
Feb 6, 2020·Frontiers in Pediatrics·Paula Méndez-AbadIsabel Benavente-Fernández
Nov 4, 2020·European Journal of Pediatrics·Agnes-Sophie FritzChristoph Hünseler
Mar 7, 2021·Pediatric Research·Catheline HocqUNKNOWN from the European Society for Pediatric Research
Apr 10, 2021·Frontiers in Pharmacology·Jeremy A ScottHartmut Grasemann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.