PMID: 9185332May 1, 1997Paper

Biochemical studies on the toxicity of 1, 1'-dimethyl-4, 4'-bipyridylium dichloride in the rat

Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology
V C Nwabisi, E A Nwanze

Abstract

The effect of intraperitoneal administration of lethal dose (50 mg/kg) of paraquat on the microsomal cysteine levels in the plasma, liver and lung of adult male Wistar rats has been investigated using Rank Chromaspek amino acid analyzer. The microsomal alanine levels were also determined to help in assessing the extent of paraquat interference with cellular protein. DL-Buthionine-[S,R]-Sulfoximine (BSO) and Diethyl maleate (DEM) were used to potentiate the toxic effect of the bipyridyl. The microsomal cysteine levels were significantly (P < or = 0.05) depressed in the plasma, liver and lung of the paraquat-treated rats compared with the saline-injected group but the alanine levels were not similarly affected. Probably, paraquat poisoning interferes specifically with the cellular cysteine content in the rat. These findings could provide a valuable information on the biochemical mechanism of paraquat intoxication.

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Citations

Mar 21, 2012·International Journal of Experimental Pathology·Rômulo D NovaesJoão Paulo V Leite
Dec 3, 2009·The Journal of Toxicological Sciences·Ana Cristina Rodrigues LacerdaCândido Celso Coimbra
Oct 25, 2011·Toxicologic Pathology·Rômulo Dias NovaesIzabel Regina Dos Santos Costa Maldonado

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