Biochemical validation of a rat model for polycystic kidney disease: comparison of guanidino compound profile with the human condition

Kidney International
A TorremansPeter Paul De Deyn

Abstract

Polycystic kidney disease (PKD) accounts for 7-10% of all dialyzed renal insufficient patients. Accumulation of specific guanidino compounds (GCs) has been related to neurological, cardiovascular, hematological, and immunological complications of renal failure. In this study, we investigate whether the PKD/Mhm rat model can be used as a biochemical model for human PKD. For the validation of the rat model, we performed the first detailed evaluation of the concentrations of GCs in serum and urine of patients with PKD in addition to the GC patterns in the plasma, urine, and tissues of the PKD/Mhm rat model. The GCs were determined after separation on a cation exchange resin and fluorescence detection. The GC levels and changes observed in blood and urine of patients with PKD are comparable with those found in patients with renal insufficiency due to different etiologies. The PKD/Mhm rat model can be used as a biochemical model for human PKD as the obvious increases of urea, guanidinosuccinic acid, creatinine, guanidine, methylguanidine, and N(G)N(G)-dimethylarginine (symmetrical dimethylarginine) seen in blood of oldest heterozygous and younger homozygous PKD rats were largely within the same range as those found in the studied hu...Continue Reading

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Citations

Aug 28, 2009·Seminars in Dialysis·Raymond VanholderAndrzej Wiecek
Oct 31, 2009·Journal of the American Society of Nephrology : JASN·Takafumi ToyoharaTakaaki Abe
May 2, 2014·Seminars in Nephrology·Rosalinde MasereeuwJerome Lowenstein
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Aug 17, 2021·Frontiers in Molecular Biosciences·Szymon MacioszekMichał J Markuszewski

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