PMID: 7546556Sep 1, 1995Paper

Biochemically active sesquiterpene lactones from Ratibida mexicana

Phytochemistry
M R CaleraRachel Mata

Abstract

Bioactivity-directed fractionation of the methanol extract of the roots of Ratibida mexicana resulted in the isolation of two bioactive sesquiterpene lactones, isoalloalantolactone and elema-1,3,11-trien-8,12-olide. Both compounds caused a significant inhibition of the radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, exerted moderate cytotoxic activity against three different solid tumour cell lines and inhibited significantly the radial growth of three phytopathogenic fungi. Isoalloalantolactone also caused the inhibition of ATP synthesis, proton uptake and electron transport (basal, phosphorylating and uncoupled) from water to methylviologen, therefore acting as a Hill's reaction inhibitor. The lactone did not affect photosystem I but inhibited photosystem II. The site of inhibition of isoalloalantolactone is located in the span of P680 to QA redox enzymes because the uncoupled electron transport from water to silicomolybdate and, from DPC to DCIP are inhibited approximately to the same extent.

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Citations

Feb 13, 2016·Acta Crystallographica. Section E, Crystallographic Communications·Abdoullah BismoussaAziz Auhmani
Sep 1, 1997·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S D LorimerN B Perry
Oct 29, 2005·Phytochemistry·Brigida D'AbroscaArmando Zarrelli
Jun 21, 2013·International Journal of Molecular Sciences·Martin ChadwickCarol Wagstaff
Jul 12, 2008·Journal of Natural Products·David Torres-RomeroIsabel L Bazzocchi
Dec 2, 1999·Journal of Natural Products·B CuiA D Kinghorn

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