Biochemically diagnosed hypothyroidism and postoperative complications after cardiac surgery: a retrospective cohort analysis

Journal of Anesthesia
Ryu KomatsuAlparslan Turan

Abstract

To determine whether hypothyroidism is associated with cardiovascular complications and surgical wound infections after cardiac surgery. Patients were categorized as: (1) hypothyroid [patients with increased TSH concentrations (≧ 5.5 mIU/L) within 6 months prior to surgery]; (2) corrected hypothyroid [diagnosis of hypothyroidism any time before surgery or on preoperative thyroid supplementation and normal TSH concentration (0.4 [Formula: see text] TSH [Formula: see text] 5.5 mIU/L]; and (3) euthyroid [no hypothyroid diagnosis and not on preoperative thyroid supplementation and normal TSH concentrations (0.4-5.5 mIU/L)]. We conducted pairwise comparisons among the three groups using inverse probability of treatment weighting. We compared the groups on postoperative myocardial infarction, cardiac arrest, atrial fibrillation, and a composite of surgical wound infections and postoperative vasopressor use using multivariable logistic regression models. We compared the groups on ICU and hospital length of stay using Cox proportional hazards regression. Hypothyroidism was associated with a lower risk of atrial fibrillation than euthyroidism, with an estimated relative risk (99.4% CI) of 0.71 (0.56, 0.89); P < 0.001. However, none of t...Continue Reading

References

Dec 1, 1977·Clinical Endocrinology·W M TunbridgeP A Smith
Aug 1, 1989·Endocrine Reviews·T J SmithC A Gorman
Aug 1, 1984·The American Journal of Medicine·P W LadensonG H Daniels
Dec 7, 1995·The New England Journal of Medicine·J D KlempererK Krieger
Aug 1, 1994·The Annals of Thoracic Surgery·T H JonesG D Angelini
Sep 1, 1993·The Annals of Thoracic Surgery·L L CreswellJ L Cox
Jul 13, 1999·Nihon Ika Daigaku zasshi·J NatoriS Tanaka
Jun 25, 2002·Asian Cardiovascular & Thoracic Annals·Aitizaz Uddin SyedMohammed R Al Fagih
Sep 23, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alfredo Giuseppe CerilloMattia Glauber
Jan 15, 2004·JAMA : the Journal of the American Medical Association·Martin I SurksNeil J Weissman
Aug 24, 2004·Thyroid : Official Journal of the American Thyroid Association·Ayse S CikimSenay Molvalilar
May 4, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Liisa KokkonenJukka Mustonen
Jun 29, 2006·The Journal of Clinical Endocrinology and Metabolism·Jose-Manuel Fernández-RealWifredo Ricart
Nov 18, 2008·European Heart Journal·Henry VölzkeMarcus Dörr
Mar 13, 2009·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·A C Thá NassifL S Nassif
Jun 30, 2009·The Annals of Thoracic Surgery·Dumbor L Ngaage, Michael E Cowen
Dec 29, 2011·Internal and Emergency Medicine·Anna BoggioAdriana Branchi

❮ Previous
Next ❯

Citations

Feb 11, 2021·Journal of Cardiac Surgery·Michelle B Mulder, Mohammed Jeraq
Feb 11, 2021·Journal of Cardiac Surgery·Dong ZhaoWei Feng
Oct 16, 2020·Interactive Cardiovascular and Thoracic Surgery·Zhen Hao AngPeter W Grant
Jan 26, 2021·The Journal of Clinical Endocrinology and Metabolism·Morgan L BrownAri J Wassner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.