Biochemistry in diagnosis and management of abnormal early pregnancy

Current Opinion in Obstetrics & Gynecology
J Elson, D Jurkovic

Abstract

This review examines the biochemical parameters of early pregnancy failure and the role that biochemical markers have to play in the selection of patients for expectant management. Earlier studies have concentrated on the role that human chorionic gonadotrophin and progesterone have to play in early pregnancy failure. Recent studies, however, have explored newer markers such as the inhibins and insulin growth factor binding proteins. Diagnostic models have now been created incorporating demographic, morphological, and biochemical parameters for the prediction of successful expectant management of early pregnancy failure. Examining the role of newer biochemical markers in early pregnancy failure has led to an improved understanding of the mechanisms behind it. Incorporation of these newer markers into diagnostic models has aided selection of patients for whom expectant management is appropriate.

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Citations

Feb 15, 2005·Prenatal Diagnosis
Nov 5, 2010·The Journal of Clinical Endocrinology and Metabolism·Andrew W HorneHilary O D Critchley
Jul 28, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Valeria RocaClaudia Pérez Leirós
Nov 28, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Valeria RocaClaudia Pérez Leirós
Apr 30, 2021·Lancet·Arri CoomarasamySiobhan Quenby

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