Biocompatibility and calcification of bovine pericardium employed for the construction of cardiac bioprostheses treated with different chemical crosslink methods

Artificial Organs
Eduardo Jorge-HerreroJosé M García Páez

Abstract

The use of biological materials in the construction of bioprostheses requires the application of different chemical procedures to improve the durability of the material without producing any undesirable effects. A number of crosslinking methods have been tested in biological tissues composed mainly of collagen. The aim of this study was to evaluate the in vitro biocompatibility, the mechanical properties, and in vivo calcification of chemically modified bovine pericardium using glutaraldehyde acetals (GAAs) in comparison with glutaraldehyde (GA) treatment. Homsy's tests showed that the most cytotoxic treatment is GA whereas GAA treatments showed lower cytotoxicity. Regarding the mechanical properties of the modified materials, no significant differences in stress at rupture were detected among the different treatments. Zeta-Potential showed higher negative values for GA treatment (-4.9 +/- 0.6 mV) compared with GAA-0.625% (-2.2 +/- 0.5 mV) and GAA-1% (-2.2 +/- 0.4 mV), which presented values similar to native tissue. Similar results were obtained for calcium permeability coefficients which showed the highest values for GA treatment (0.12 +/- 0.02 mm(2)/min), being significantly lower for GAA treatments or non-crosslinked perica...Continue Reading

References

Jan 1, 1992·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·F J Schoen, R J Levy
Aug 1, 1992·Matrix : Collagen and Related Research·K AnselmeD Herbage
Mar 1, 1991·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·D TrigliaG K Naughton
Sep 1, 1990·Journal of Biomedical Materials Research·L L Huang-LeeM E Nimni
Jan 1, 1990·Annual Review of Medicine·G L Grunkemeier, S H Rahimtoola
Nov 1, 1989·Journal of Biomedical Materials Research·E EyblE Wolner
Sep 1, 1988·The Annals of Thoracic Surgery·I VeselyT Song
Sep 1, 1984·Journal of Biomedical Materials Research·E GendlerM E Nimni
Aug 1, 1994·Biomaterials·E Jorge-HerreroJ L Castillo-Olivares
Feb 1, 1994·Journal of Biomedical Materials Research·H PetiteD Herbage
Aug 8, 1996·The New England Journal of Medicine·W VongpatanasinR A Lange
Apr 1, 1996·Biomaterials·L H Olde DaminkJ Feijen
Mar 1, 1996·Biomaterials·A Jayakrishnan, S R Jameela
Mar 15, 1997·Journal of Biomedical Materials Research·L M BiedrzyckiF J Schoen
Jun 15, 1997·Journal of Biomedical Materials Research·M E NimniB Han
Dec 5, 1998·Biomaterials·J ChandaR Kuribayashi
Sep 28, 2000·Journal of Biomedical Materials Research·I M KhouwM J van Luyn
Jul 9, 2002·Biomaterials·P CaleroJ L Castillo-Olivares
Sep 26, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·I Vesely
Oct 21, 2003·Journal of Biomedical Materials Research. Part a·Lorella MarinucciPaola Locci
Jan 27, 2004·Electrophoresis·Brian J Kirby, Ernest F Hasselbrink
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·E Jorge-HerreroJ L Castillo-Olivares
Aug 19, 2007·Journal of Materials Science. Materials in Medicine·Sergio A Yoshioka, G Goissis
Oct 24, 2007·Biomaterials·Peter ZillaDeon Bezuidenhout
Jun 3, 2008·Biomaterials·Leigh G GriffithsE Christopher Orton
Jun 14, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Elena PettenazzoGaetano Thiene
Nov 1, 1996·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·A SimionescuR F Deac

❮ Previous
Next ❯

Citations

Oct 30, 2012·Journal of Materials Science. Materials in Medicine·Roman A Perez, Maria-Pau Ginebra
May 15, 2013·Journal of Materials Science. Materials in Medicine·Terry W J SteeleSubbu S Venkatraman
Mar 16, 2011·Artificial Organs·Paul S Malchesky
Apr 17, 2012·Journal of Biomedicine & Biotechnology·Holger KochAndreas Boldt
Apr 7, 2015·Materials Science & Engineering. C, Materials for Biological Applications·S JahnaviR S Verma
Mar 19, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Birzabith Mendoza-NoveloGustavo V Guinea
Nov 26, 2010·Acta Biomaterialia·Birzabith Mendoza-NoveloJosé L Mata-Mata
Sep 30, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yang LeiYunbing Wang
Feb 23, 2020·Biotechnology Journal·Ekaterina A GrebenikPeter S Timashev
Mar 10, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Li YangYunbing Wang
May 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Birzabith Mendoza-NoveloÁngel Marcos-Fernández
May 27, 2021·Advanced Healthcare Materials·Hieu T BuiLakshmi Prasad Dasi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Artificial Heart & Ventricular Assist Devices

Total artificial hearts (TAH) and ventricular assist devices (VADs) provide cardiac support for patients with end-stage heart disease and have significantly improved the survival of these patients. Discover the latest research on Artificial Heart and Ventricular Assist Devices here.