Biocompatibility and degradation of tendon-derived scaffolds

Regenerative Biomaterials
Kyle A Alberti, Qiaobing Xu

Abstract

Decellularized extracellular matrix has often been used as a biomaterial for tissue engineering applications. Its function, once implanted can be crucial to determining whether a tissue engineered construct will be successful, both in terms of how the material breaks down, and how the body reacts to the material's presence in the first place. Collagen is one of the primary components of extracellular matrix and has been used for a number of biomedical applications. Scaffolds comprised of highly aligned collagen fibrils can be fabricated directly from decellularized tendon using a slicing, stacking, and rolling technique, to create two- and three-dimensional constructs. Here, the degradation characteristics of the material are evaluated in vitro, showing that chemical crosslinking can reduce degradation while maintaining fiber structure. In vivo, non-crosslinked and crosslinked samples are implanted, and their biological response and degradation evaluated through histological sectioning, trichrome staining, and immunohistochemical staining for macrophages. Non-crosslinked samples are rapidly degraded and lose fiber morphology while crosslinked samples retain both macroscopic structure as well as fiber orientation. The cellular r...Continue Reading

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Citations

Aug 10, 2016·ACS Applied Materials & Interfaces·Eunkyung KoSeung-Woo Cho
Jun 22, 2016·Journal of Biomedical Materials Research. Part a·Salim A Ghodbane, Michael G Dunn
Feb 15, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Marek KaweckiAleksandra Kasperczyk
Jan 30, 2018·Tissue Engineering. Part a·Sheila A GrantDavid A Grant
Jan 27, 2019·Journal of Biomedical Materials Research. Part a·Samaneh GhazanfariAli Khademhosseini
Jul 18, 2018·International Journal of Molecular Sciences·Anke LohanGundula Schulze-Tanzil
May 8, 2018·PeerJ·Marcello de Alencar SilvaMaria Acelina Martins de Carvalho
Oct 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min Guk Kim, Chan Ho Park
Oct 15, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jie LiaoXiaoming Li
Jul 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuhong QianZhuang Li
Jun 13, 2016·ACS Biomaterials Science & Engineering·Kyle A AlbertiQiaobing Xu

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Methods Mentioned

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