Biocompatibility and fatigue properties of polystyrene-polyisobutylene-polystyrene, an emerging thermoplastic elastomeric biomaterial

Biomacromolecules
Miroslawa El FrayVolker Altstädt

Abstract

This paper will discuss the biocompatibility and dynamic fatigue properties of polystyrene-b-polyisobutylene-b-polystyrene thermoplastic elastomer with 30 wt % polystyrene (SIBS30), an emerging FDA-approved biomaterial. SIBS30 is a very soft, transparent biomaterial resembling silicone rubber, with superior mechanical properties. Using the hysteresis method adopted for soft biomaterials, the dynamic fatigue properties of SIBS30 were found to be between those of polyurethane and silicone rubber, with fatigue life twice as long as that of silicone. Under single load testing (SLT, 1.25 MPa), SIBS30 displayed less than half the dynamic creep compared to silicone, both in air and in vitro (37 degrees C, simulated body fluid). Hemolysis and 30- and 180-day implantation studies revealed excellent biocompatibility of the new biomaterial. The results presented in this paper indicate that, in comparison with silicone rubber, SIBS30 has similar biocompatibility and superior dynamic fatigue properties.

References

Mar 25, 1994·Science·N A Peppas, R Langer
May 17, 2006·Acta Biomaterialia·Shrirang V RanadeMichael N Helmus

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Citations

May 7, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Thomas E ClaiborneDanny Bluestein
Mar 1, 2013·Journal of Biomechanical Engineering·Thomas E ClaiborneDanny Bluestein
Dec 20, 2012·Expert Review of Medical Devices·Thomas E ClaiborneDanny Bluestein
Mar 8, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Goy Teck LimSteven P Schmidt
Dec 26, 2009·Biomaterials·Judit E PuskasKrystal Lovejoy
Oct 20, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Andrew T MillerKen Gall
Jun 2, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Shiny VelayudhanJustin Cooper-White
Jan 6, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Judit E PuskasGreg Haugstad
Oct 4, 2011·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Judit E Puskas, Matthew T Luebbers
Jul 2, 2009·Journal of Biomedical Materials Research. Part a·Qiang WangRichard T Schoephoerster
Aug 27, 2013·Journal of the Mechanical Behavior of Biomedical Materials·E B van der HouwenG J Verkerke
Sep 1, 2014·Journal of the Mechanical Behavior of Biomedical Materials·C GötzV Altstädt
Nov 2, 2011·Journal of Biotechnology·Muhammad NoorUlrich Schwaneberg
Aug 2, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Mauro Fittipaldi, Landon R Grace
Dec 31, 2015·Journal of Biomedical Materials Research. Part a·M Jane BrennanJulie C Liu
Feb 6, 2017·Journal of the Mechanical Behavior of Biomedical Materials·Mauro Fittipaldi, Landon R Grace
Mar 29, 2016·Journal of Biomechanical Engineering·M SerraniG D Moggridge
Apr 7, 2019·Hernia : the Journal of Hernias and Abdominal Wall Surgery·B EastA C de Beaux
Sep 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lixia BaoJiliang Wang
Dec 23, 2015·The International Journal of Artificial Organs·Francesco De GaetanoMaria Laura Costantino
Feb 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuaishuai YuanJinghua Yin
Aug 14, 2019·Circulation. Arrhythmia and Electrophysiology·Mark D McCauleyMatteo Pasquali
Mar 27, 2020·Materials Today. Bio·F OveissiF Dehghani
Nov 12, 2018·ACS Biomaterials Science & Engineering·Jackson T LewisTravis S Bailey

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