Biocompatibility and resorption pattern of newly developed hyaluronic acid hydrogel reinforced three-layer poly (lactide-co-glycolide) membrane: histologic observation in rabbit calvarial defect model

Biomaterials Research
Hoon YouSeong-Ho Choi

Abstract

The aim of this study was to evaluate the biocompatibility and resorption pattern in three-layer poly (lactide-co-glycolide) (PLGA) membrane according to the concentrations of hyaluronic acid (HA) hydrogel in rabbit calvarial defect model. Four standardized circular defects with 8 mm diameter were created on the four rabbit calvarium. Three-layer PLGA membranes (5% and 10% HA gel) were used as the test groups, both collagen membrane and monolayer PLGA membrane as the control groups. After sacrificing the animals after 4 and 8 weeks, block sections were harvested and histological observation was performed. Pus formation was observed in a site on the three-layer PLGA membranes (with 10% HA gel) of 4 weeks group and initial inflammatory responses were observed on the three-layer PLGA membrane group. However, when compared to both the monolayer PLGA membrane group and collagen membrane group, the HA gel-reinforced three-layer PLGA membrane showed improved cell occlusion and retention period, showing the formation of the capsule-like structure. There was no definite difference between the results of the membranes fabricated with either 5% or 10% HA hydrogel. The HA reinforced three-layer PGLA membrane was retained longer than contro...Continue Reading

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Citations

Nov 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ji Hoon ParkMoon Suk Kim
Oct 11, 2017·Journal of Tissue Engineering·Tarek M BedairDong Keun Han
Feb 19, 2015·Journal of Biomedical Materials Research. Part a·Sung Chul ChoiChan-Wha Kim

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