Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems

Chemical Engineering Journal
Dana da SilvaAvi Schroeder

Abstract

Polylactic acid (PLA) is the most commonly used biodegradable polymer in clinical applications today. Examples range from drug delivery systems, tissue engineering, temporary and long-term implantable devices; constantly expanding to new fields. This is owed greatly to the polymer's favorable biocompatibility and to its safe degradation products. Once coming in contact with biological media, the polymer begins breaking down, usually by hydrolysis, into lactic acid (LA) or to carbon dioxide and water. These products are metabolized intracellularly or excreted in the urine and breath. Bacterial infection and foreign-body inflammation enhance the breakdown of PLA, through the secretion of enzymes that degrade the polymeric matrix. The biodegradation occurs both on the surface of the polymeric device and inside the polymer body, by diffusion of water between the polymer chains. The median half-life of the polymer is 30 weeks; however, this can be lengthened or shortened to address the clinical needs. Degradation kinetics can be tuned by determining the molecular composition and the physical architecture of the device. Using L- or D- chirality of the LA will greatly slow or lengthen the degradation rates, respectively. Despite the f...Continue Reading

Citations

Jul 31, 2019·Journal of Biomaterials Science. Polymer Edition·Rongying GuoXiufeng Xiao
May 20, 2020·Advanced Healthcare Materials·Fan Zhang, Martin W King
Feb 13, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Soo-Hwan ByunJong-Ho Lee
Feb 12, 2020·Advanced Science·Julieta M SánchezAntonio Villaverde
May 22, 2020·Journal of Thermal Analysis and Calorimetry·Karolina Kosowska, Piotr Szatkowski
Oct 3, 2018·International Journal of Biomaterials·Yaowalak SrisuwanSupakij Suttiruengwong
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Eli J CurryThanh D Nguyen
Nov 21, 2020·Membranes·Monika WasyłeczkoAndrzej Chwojnowski
Oct 28, 2020·Artificial Organs·Heather HolmanTaufiek Konrad Rajab
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Robin AugustineAla-Eddin Al Moustafa
Jan 29, 2021·Regional Anesthesia and Pain Medicine·Carles García-VitoriaJose I Redondo
Dec 18, 2020·Frontiers in Cardiovascular Medicine·Xuan Mei, Ke Cheng
Dec 6, 2020·Scientific Reports·Keivan KeramatzadehAmir M Sodagar
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Petra AranyIldikó Bácskay
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Xiaoxuan DengM Azam Ali
Dec 31, 2020·Polymers·Julia Sánchez-BodónMª Isabel Moreno-Benítez
Jan 29, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad Umar Aslam KhanRashid Amin
Feb 20, 2021·Pharmaceutical Research·Sara Rhaissa Rezende do ReisRalph Santos-Oliveira
Mar 2, 2021·Macromolecular Bioscience·Fernando Gisbert RocaCristina Martínez-Ramos
Mar 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Behzad Shiroud HeidariBarry Doyle
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raasti NaseemKenny Dalgarno
Feb 28, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Soma PatnaikPrashant Kesharwani
Mar 21, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Amirpasha MoetazedianVadim V Silberschmidt
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Raúl Vallejos BaierJuan F Vivanco
Mar 25, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Habib BelaidMikhael Bechelany
May 9, 2021·Acta Biomaterialia·Cheng LinJinsong Leng
May 24, 2021·Analytica Chimica Acta·M GrajewskiG Ij Salentijn

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