PMID: 11920676Mar 29, 2002Paper

Biocompatibility evaluation of ePTFE membrane modified with PEG in atmospheric pressure glow discharge

Journal of Biomedical Materials Research
Qing ZhangMakoto Kodama

Abstract

ePTFE membranes were modified by poly(ethylene glycol) having a molecular weight of 600 (PEG-600) in atmospheric pressure glow discharge (APG) plasma treatment. ePTFE membranes were immersed in 1%, 3%, or 5% (w/v) PEG-600 in dehydrated ethanol. PEG-600-penetrated ePTFE membranes were dried in a vacuum to immediately remove ethanol, then treated with APG at 20 kHz and 60-70 W for 15 min and thoroughly washed with ethanol and water. PEG-600-modified ePTFE membranes were analyzed using contact angle measurement, Fourier transform infrared attenuated total reflectance (FTIR-ATR), and scanning electron microscopy (SEM). ePTFE membrane contact angles were reduced after PEG-600 plasma treatment. FTIR-ATR spectra showed an absorption band due to a PEG hydroxyl group (-OH). SEM showed that ePTFE fiber surfaces were uniformly immobilized with PEG-600 and retained their porous structure. A general biological evaluation of the PEG-modified ePTFE membranes showed no cytotoxicity on CHO-K1 cell lines and no hemolytic action. Albumin adsorption on the PEG-modified ePTFE membranes increased with increasing PEG-600 deposited on ePTFE membranes. Fibrinogen adsorption decreased with increasing PEG-600 deposited on ePTFE membranes. gamma-Globulin ...Continue Reading

References

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Apr 1, 1993·Biomaterials·Y C TsengK Park
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Citations

May 8, 2007·Journal of Materials Science. Materials in Medicine·D Sakthi KumarYasuhiko Yoshida
Mar 28, 2009·Journal of Biomaterials Science. Polymer Edition·Shuwu WangRoger E Marchant
Mar 31, 2005·Journal of Colloid and Interface Science·Soo-Jin Park, Hwa-Young Lee
Sep 1, 2005·Macromolecular Bioscience·Pascale ChevallierGaétan Laroche
Jul 15, 2017·Journal of Materials Science. Materials in Medicine·Victoria R KearnsRachel L Williams

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