PMID: 8463972Apr 1, 1993Paper

Biocompatibility: its future in prosthodontic research

The Journal of Prosthetic Dentistry
M Edgerton, M J Levine

Abstract

The future of prosthodontic research will involve replacing lost tissues by using scientific methods that evaluate biomaterials and treatment designs based on desired biologic outcomes. The present concept of a biocompatible material is one that elicits an appropriate host response in a specific application. To design optimal biomaterials, three interactive components should be considered: the chemical nature of the surface, the mediating pellicle layer, and microbial and host response. Surface chemistry determines which molecules are selectively absorbed onto a surface from oral fluids. The pellicle-coated surface should be designed to elicit a more desirable host response. Pellicle composition can be altered by chemically changing the surface, precoating surfaces with biological molecules, or using synthetic materials designed to mimic natural tissues. Several surface-sensitive techniques are available to assess these modifications, including vibrational spectroscopy, electron microscopy for chemical analysis, and bioanalytical methods. To develop more biocompatible materials, a further understanding of pellicle formation as a function of surface composition, microbial adhesion to biomaterials, and cellular reaction to implan...Continue Reading

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Citations

Feb 20, 2007·Applied and Environmental Microbiology·Rainer MüllerStefan Ruhl
Oct 18, 2016·Drug Delivery·Gurmeet KaurAmit K Goyal
Jun 25, 2005·Journal of Oral Rehabilitation·M S YildirimN Sultan
Aug 30, 2006·Journal of Oral Rehabilitation·M S YildirimU Hasanreisoğlu
Jul 29, 2015·Biomaterials Science·Christophe BlaszykowskiMichael Thompson

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