Biocompatibility of a new bioabsorbable radiopaque stent material (BaSO4 containing poly-L,D-lactide) in the rat pancreas

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Teemu LämsäIsto Nordback

Abstract

During recent years, we have been developing bioabsorbable biliary stents with promising experimental results. In developing pancreatic stents before long-term experiments, the acute toxicity to the pancreas of a bioabsorbable, radiopaque polylactide (PLA 96-barium sulfate, BaSO4) stent material was investigated. The pancreas of 65 Sprague-Dawley rats was exposed either to radiopaque stent material [PLA 96 with 25% (w/w) of BaSO4], radiolucent stent material (PLA 96), or inert steel by inserting a 5-mm-long (diameter 0.3 mm) fiber/stick of material into the pancreas after laparotomy under general anesthesia. Pancreatic tissue specimens and blood samples were taken after 1, 3, 7, and 21 days for histological examination and amylase activity measurements. Samples were also taken from 5 baseline (control) rats without exposing to any materials. The baseline serum amylase activity was normal, and no histological changes in the pancreas were observed. A significant increase (mean +/- SE) in the serum amylase activity was observed only on day 1 in the animals having radiopaque stent material (PLA 96-BaSO4; 5,845 +/- 1,135 U/l), steel (4,946 +/- 667 U/l), or radiolucent stent material (PLA 96; 7,684 +/- 667 U/l) inserted. There was sl...Continue Reading

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Citations

Jun 13, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Isto NordbackJuhani Sand
Jun 3, 2008·Gastrointestinal Endoscopy·Deepak K Bhasin, Surinder S Rana
May 29, 2007·Gastrointestinal Endoscopy·Johanna LaukkarinenJuhani Sand
Dec 30, 2010·IEEE Transactions on Bio-medical Engineering·Christopher B ArenaRafael V Davalos
Apr 18, 2016·Advanced Drug Delivery Reviews·Marius Murariu, Philippe Dubois
Oct 9, 2018·Advanced Healthcare Materials·Mohamed F AttiaFrank Alexis
Nov 28, 2018·Scientific Reports·Hui Ying AngYingying Huang
Nov 7, 2019·Nanomaterials·Kateřina ŠkrlováDaniela Plachá
Sep 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Żaneta GóreckaWojciech Swięszkowski

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