Biocompatibility of calcium phosphate bone cement with optimized mechanical properties

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Iwan PalmerSusan A Clarke

Abstract

The broad aim of this work was to investigate and optimize the properties of calcium phosphate bone cements (CPCs) for use in vertebroplasty to achieve effective primary fixation of spinal fractures. The incorporation of collagen, both bovine and from a marine sponge (Chondrosia reniformis), into a CPC was investigated. The biological properties of the CPC and collagen-CPC composites were assessed in vitro through the use of human bone marrow stromal cells. Cytotoxicity, proliferation, and osteoblastic differentiation were evaluated using lactate dehydrogenase, PicoGreen, and alkaline phosphatase activity assays, respectively. The addition of both types of collagen resulted in an increase in cytotoxicity, albeit not to a clinically relevant level. Cellular proliferation after 1, 7, and 14 days was unchanged. The osteogenic potential of the CPC was reduced through the addition of bovine collagen but remained unchanged in the case of the marine collagen. These findings, coupled with previous work showing that incorporation of marine collagen in this way can improve the physical properties of CPCs, suggest that such a composite may offer an alternative to CPCs in applications where low setting times and higher mechanical stability...Continue Reading

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Citations

Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Tianjue WangHongzhi Zhou
May 12, 2017·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Johannes SchauweckerChlodwig Kirchhoff
Jan 10, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Anja KleinAlexander Hofmann
Mar 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Weiwei LiangXuliang Deng
Oct 15, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Manish KumarSanjeevi Kannan
Nov 16, 2016·Journal of Materials Science. Materials in Medicine·Iwan PalmerSusan A Clarke

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BETA
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scanning electron microscopy

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