PMID: 6334194Aug 1, 1984

Biocompatibility of dialysis membranes: effects of chronic complement activation

Kidney International
R M HakimJ M Lazarus

Abstract

The ability of three dialysis membranes (cuprophane, cellulose acetate, and polymethylmethacrylate) to activate complement was studied prospectively in ten chronic dialysis patients using new and reused membranes. Patients were dialyzed for 1 month with each type of membrane. New cuprophane membranes caused the most intense activation, while polymethylmethacrylate (PMMA) surfaces caused the least degree of complement activation. Reuse decreases the capacity of the cuprophane membrane to activate complement but does not significantly alter the capacity of cellulose acetate membranes. The extent of complement activation paralleled the ability of these membranes to induce neutropenia. Recurrent dialysis with new cuprophane and cellulose acetate membranes leads to a decrease in pre-dialysis and "rebound leukocytosis" neutrophil count, as well as a more intense activation of complement and an enhanced endogenous clearance of products of complement activation. The clinical sequelae of recurrent complement activation are discussed.

References

Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D E Chenoweth, T E Hugli
Jan 1, 1977·Acta Haematologica·U Sjögren, H Thysell
Nov 1, 1979·Archives of Internal Medicine·K A NsouliM Shocair
Jul 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L W HendersonD E Chenoweth
Dec 1, 1983·Kidney International·P IvanovichD E Hammerschmidt
Dec 1, 1983·Kidney International·D E ChenowethL W Henderson
Dec 1, 1983·Kidney International·D E ChenowethL W Henderson
May 1, 1981·Kidney International·K S KantR Berlin
May 1, 1983·Kidney International·W A De BackerM E De Broe
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S K LawR P Levine

Citations

Apr 1, 1993·Journal of Biomedical Materials Research·S ParzerC Mannhalter
Oct 16, 2002·Journal of Clinical Apheresis·Katsuhiko YonemuraAkira Hishida
Nov 1, 1984·American Journal of Surgery·T Kunitomo
Feb 25, 1998·Transplantation Proceedings·H SetoyamaY Ikada
Aug 10, 1999·Critical Reviews in Oncology/hematology·L L Horstman, Y S Ahn
Oct 4, 1984·The New England Journal of Medicine·R M HakimF K Port
Feb 21, 1985·The New England Journal of Medicine·M A ArnaoutH R Colten
Feb 21, 1985·The New England Journal of Medicine·M Texon
Jun 13, 1985·The New England Journal of Medicine
Feb 1, 1986·Artificial Organs·S M Ringoir, R Vanholder
Apr 1, 1986·Artificial Organs·S Murabayashi, Y Nosé
Apr 1, 1987·Artificial Organs·R Vanholder, S M Ringoir
Apr 1, 1987·Artificial Organs·T BoschH J Gurland
May 1, 1996·Artificial Organs·H KlinkmannJ Vienken
Feb 1, 1994·Journal of Clinical Pathology·A InnesR J Powell
Jan 1, 1997·Annual Review of Medicine·M PascualN Tolkoff-Rubin
Jun 3, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·G F KörmöcziG J Zlabinger
Nov 16, 2010·International Reviews of Immunology·C LibettaA Dal Canton
Dec 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·F KnudsenC Jersild
Aug 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B J PereiraC A Dinarello
Apr 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M CardosoL Lapierre
Dec 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A K Cheung
Sep 1, 1992·Kidney International·R Vanholder, S M Ringoir
May 1, 1991·Journal of Biomedical Materials Research·S OmokawaY Nosé
Feb 1, 1989·Kidney International·A K CheungJ Janatova
Feb 1, 1996·Kidney International·M PascualJ A Schifferli
Sep 1, 1993·Kidney International·R M Hakim
Jul 1, 1993·Kidney International·R VanholderS M Ringoir
Apr 1, 1995·Kidney International·S M Baumgartner-ParzerC Mannhalter
May 1, 1991·Kidney International·L A HebertJ C Neff
Jul 1, 1987·Kidney International·R VanholderS M Ringoir
Jan 1, 1987·Kidney International·S L LewisD E Chenoweth
Jan 1, 1988·Kidney International·G LonnemannC A Dinarello
Apr 1, 1993·Kidney International·M Pascual, J A Schifferli
Aug 1, 1994·Kidney International·M P GawazH J Gurland
May 1, 1989·Kidney International·N Haeffner-CavaillonM D Kazatchkine
Feb 1, 1990·Kidney International·R A WardH J Gurland
Feb 1, 1990·Kidney International·R M Hakim
Jun 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N R SkroederS H Jacobson
Dec 10, 1991·Clinical Materials·R Vanholder
Apr 1, 1989·British Journal of Urology·P GarredB E Glahn
Feb 16, 2000·Lancet·R A Star, P L Kimmel
Apr 1, 1985·The American Journal of Medicine·R M Hakim, A I Schafer
Feb 9, 1999·Artificial Organs·M P GawazH J Gurland
Jan 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·E D HynoteP A Davis
Jan 4, 1998·Journal of Biomedical Materials Research·J HonigerL Laroche
Feb 9, 1999·Artificial Organs·M BonominiN Settefrati
May 11, 1992·Arthritis and Rheumatism·E M GravalleseW F Owen
May 22, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Samuel CaillouPaul G Rouxhet
Jul 27, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Ke WangHFM Study
Jan 10, 2006·Journal of Biomedical Materials Research. Part a·Saotomo ItohTsutomu Tsuji
May 16, 2020·International Journal of Molecular Sciences·Vincenzo LosappioGiovanni Stallone
Feb 1, 1990·Anaesthesia and Intensive Care·D M Dickson, K M Hillman
Jul 16, 2002·The International Journal of Artificial Organs·V SirolliM Bonomini
Jun 3, 2017·The International Journal of Artificial Organs·Carina ZweigartBernd Krause
Sep 1, 1993·Artificial Organs·A A AlarabiB G Danielson
May 8, 2018·Nature Reviews. Nephrology·Claudio Ronco, William R Clark
Apr 10, 2019·Polymers·Marina VoinovaLeonid Gorelik
Aug 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Panmiao LiuZhongze Gu

Related Concepts

Acetylcellulose
Cuprammonium cellulose
Hemocompatible Materials
Sulfite Cellulose
Complement Activation
Complement C3 precursor
Hemodialysis
Kidney Failure, Chronic
Differential White Blood Cell Count Procedure
Membranes, Artificial

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