Biocompatibility of electrospun human albumin: a pilot study

Biofabrication
B H NoszczykZ Pojda

Abstract

Albumin is rarely used for electrospinning because it does not form fibres in its native globular form. This paper presents a novel method for electrospinning human albumin from a solution containing pharmaceutical grade protein and 25% polyethylene oxide (PEO) used as the fibre-forming agent. After spontaneous cross-linking at body temperature, with no further chemicals added, the fibres become insoluble and the excess PEO can be washed out. Albumin deposited along the fibres retains its native characteristics, such as its non-adhesiveness to cells and its susceptibility for degradation by macrophages. To demonstrate this we evaluated the mechanical properties, biocompatibility and biodegradability of this novel product. After subcutaneous implantation in mice, albumin mats were completely resorbable within six days and elicited only a limited local inflammatory response. In vitro, the mats suppressed cell attachment and migration. As this product is inexpensive, produced from human pharmaceutical grade albumin without chemical modifications, retains its native protein properties and fulfils the specific requirements for anti-adhesive dressings, its clinical use can be expedited. We believe that it could specifically be used w...Continue Reading

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Citations

May 15, 2016·Journal of Colloid and Interface Science·Arjun Prasad TiwariCheol Sang Kim
Nov 20, 2016·BioFactors·Dénes B HorváthyZsombor Lacza
Jan 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao TaoDong-An Wang

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