Biocompatibility of extracorporeal immunoadsorption systems

Transfusion Science
J G Kadar, H Borberg

Abstract

Following the first publication of a technique aiming for clinical application in 1969, extracorporeal immunoadsorption is increasingly finding a place among haemapheresis techniques. The apparent advantages outweigh the technical difficulties and economical drawbacks still connected with this treatment modality. At present three different developments are under clinical investigation: Staphylococcus Protein-A based immunoadsorption (SpA), the antibody-mediated adsorption (therapeutic affinity chromotography) and hydrophobic interaction-based immunoglobulin adsorption. The exact binding capacity and mechanism has not been completely elucidated for SpA and amino acid-based techniques. The lack of knowledge about pathogenic substrates exclusively responsible for the pathogenicity of many diseases, appears to be the major drawback for the prospective development of affinity chromatography-based extracorporeal systems. The practical application of molecular-biologic diagnostic procedures with a high grade of detection specificity (monoclonal antibodies) appears to be promising for the development of extracorporeal immunoadsorption. The immunomodulatory effect that results from the interaction of blood and plasma with artificial sur...Continue Reading

References

Mar 31, 1989·Journal of Immunological Methods·H SatoM Hori
Jan 1, 1988·Journal of Clinical Apheresis·H BorbergW Stoffel
Jan 1, 1985·Vox Sanguinis·W I BensingerR A Clift
Sep 1, 1984·Biomaterials·T UchidaY Murao
Oct 4, 1984·The New England Journal of Medicine·R M HakimF K Port
Aug 1, 1983·The Journal of Experimental Medicine·M J Polley, R L Nachman
Nov 1, 1983·Artificial Organs·B C McLeodR J Sassetti
Apr 15, 1982·The New England Journal of Medicine
Jan 1, 1980·Journal of Dialysis·J ShinM Nishioka

Citations

Jan 6, 2010·Archives of Dermatological Research·E Schmidt, D Zillikens
May 4, 2005·Human Immunology·Junchao Cai, Paul I Terasaki
Jul 15, 2011·Artificial Organs·Tsung-Hua YangKang-Ju Chou
Oct 27, 2015·Archives of Dermatological Research·Michael MersmannE Schmidt
Sep 24, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Michael Gräf, Johannes Weihs
Sep 18, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Michael GräfJoachim Esser

Related Concepts

Indirect Thrombin Inhibitors
Hemocompatible Materials
Chromatography, Affinity
Future
Immunosorbent Techniques
Plasmapheresis
Staphylococcal Protein A

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