Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility

Biomaterials
E FournierJ P Benoit

Abstract

Numerous polymeric biomaterials are implanted each year in human bodies. Among them, drug delivery devices are potent novel powerful therapeutics for diseases which lack efficient treatments. Controlled release systems are in direct and sustained contact with the tissues, and some of them degrade in situ. Thus, both the material itself and its degradation products must be devoid of toxicity. The knowledge and understanding of the criteria and mechanisms determining the biocompatibility of biomaterials are therefore of great importance. The classical tissue response to a foreign material leads to the encapsulation of the implant, which may impair the drug diffusion in the surrounding tissue and/or cause implant failure. This tissue response depends on different factors, especially on the implantation site. Indeed, several organs possess a particular immunological status, which may reduce the inflammatory and immune reactions. Among them, the central nervous system is of particular interest, since many pathologies still need curative treatments. This review describes the classical foreign body reaction and exposes the particularities of the central nervous system response. The recent in vivo biocompatibility studies of implanted ...Continue Reading

References

Feb 20, 1978·Acta Neuropathologica·S S Stensaas, L J Stensaas
Jan 1, 1992·Biomaterials·A Remes, D F Williams
Feb 1, 1989·Journal of Biomedical Materials Research·R J TamargoH Brem
Jan 1, 1989·Selective Cancer Therapeutics·H BremK W Leong
Aug 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R E Marchant
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
Jun 1, 1995·Journal of Biomedical Materials Research·W F den DunnenJ M Schakenraad
Sep 1, 1994·Journal of Biomedical Materials Research·P MeneiJ P Benoit
May 1, 1994·Journal of Neuropathology and Experimental Neurology·M D Norenberg
Dec 1, 1995·Journal of the Neurological Sciences·K D Barron
Feb 1, 1997·Human Immunology·J W StreileinA W Taylor
May 1, 1997·Journal of Neuroimmunology·G PryceJ Greenwood
May 1, 1997·Immunology Today·T S Griffith, T A Ferguson
Sep 1, 1997·Clinical Immunology and Immunopathology·J J Letterio, A B Roberts
Feb 11, 1998·Journal of Biomedical Materials Research·M ZignaniR Gurny
Mar 6, 1998·Nature Biotechnology·L H KooleF H van der Veen
May 26, 1998·Journal of the Neurological Sciences·B G Xiao, H Link
Jun 10, 1998·Cytokine & Growth Factor Reviews·B M Pratt, J M McPherson
Jun 27, 1998·The Journal of Pharmacy and Pharmacology·I F UchegbuE Mosha
Aug 5, 1998·Biomaterials·S M IbimC T Laurencin
Nov 21, 1998·Critical Reviews in Therapeutic Drug Carrier Systems·K P Vercruysse, G D Prestwich
Dec 22, 1998·Journal of Biomaterials Science. Polymer Edition·L Tang
Feb 11, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·J M Anderson, J J Langone
Jul 9, 1999·Journal of Biomedical Materials Research·M A RoyalsR L Dunn
Nov 2, 1999·The Journal of Experimental Medicine·S Hong, L Van Kaer
Mar 1, 2000·Journal of Neuroimmunology·A R DixL A Morford
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·R L GutmanD R Lu
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·M V SeftonJ E Babensee
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Y NgJ Heller
Apr 11, 2000·Journal of Biomedical Materials Research·S EinmahlR Gurny
May 18, 2000·Journal of Neuroimmunology·A CornetR S Liblau

❮ Previous
Next ❯

Citations

Jun 8, 2010·Journal of Materials Science. Materials in Medicine·Saurabh VijayDipak K Majumdar
Aug 6, 2010·Journal of Materials Science. Materials in Medicine·Nazar M RanjhaMuhammad Tayyab Ansari
Dec 18, 2008·Pharmaceutical Research·Chien-Chi Lin, Kristi S Anseth
Mar 19, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Morten DahlElse Marie Pinholt
Mar 17, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Elvire FournierJean-Pierre Benoit
Dec 15, 2007·Neuron Glia Biology·Erin D MilliganMelissa J Mahoney
Jan 19, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Hui XieJeffrey W Smith
Jan 15, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Ashwin NairLiping Tang
May 15, 2008·Journal of the Royal Society, Interface·Yinghui Zhong, Ravi V Bellamkonda
Aug 20, 2010·Journal of the Royal Society, Interface·Kangwon LeeDavid J Mooney
Apr 5, 2007·Biomagnetic Research and Technology·Hong ZhaoUrs O Häfeli
Aug 17, 2010·Journal of Nanobiotechnology·Hui Xie, Jeffrey W Smith
Feb 10, 2010·The AAPS Journal·Jacqueline M MoraisDiane J Burgess
Jul 27, 2012·Therapeutic Delivery·Robert Loch MacdonaldTom Tice
Mar 9, 2012·Regenerative Medicine·Sárka Kubinová, Eva Syková
Apr 13, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·C GujralT Nakaji-Hirabayashi
Oct 1, 2013·Drug Delivery and Translational Research·Byeong Hee HwangSamir Mitragotri
Feb 2, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·C BastiancichF Danhier
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Ali Pourjavadi, Zahra Mazaheri Tehrani
Feb 22, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·So-Youn MinChandra Mohan
Dec 24, 2011·Neuroscience Research·Emily R AurandKimberly B Bjugstad
Nov 17, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Van-Thanh TranMarie-Claire Venier-Julienne
May 4, 2011·International Journal of Pharmaceutics·Maha CheddadiAna Fernández-Carballido
Feb 16, 2011·Biomaterials·Sanja B TurturroJennifer J Kang-Mieler
Mar 18, 2010·Acta Biomaterialia·SuXiu NgSay Chye Joachim Loo
Sep 28, 2015·Journal of the Mechanical Behavior of Biomedical Materials·R ScaffaroG Ghersi
Jan 27, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·D KloseJ Siepmann
Dec 7, 2007·International Journal of Pharmaceutics·D KloseJ Siepmann
Dec 29, 2007·International Journal of Pharmaceutics·A GiteauJ P Benoit
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Muhammad AkramMuhammad Saleem

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