Biocompatibility of mannan nanogel--safe interaction with plasma proteins

Biochimica Et Biophysica Acta
Sílvia A FerreiraTommy Cedervall

Abstract

Self-assembled mannan nanogels are designed to provide a therapeutic or vaccine delivery platform based on the bioactive properties of mannan to target mannose receptor expressed on the surface of antigen-presenting cells, combined with the performance of nanogels as carriers of biologically active agents. Proteins in the corona around mannan nanogel formed in human plasma were identified by mass spectrometry after size exclusion chromatography or centrifugation followed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Structural changes and time dependent binding of human apolipoprotein A-I (apoA-I) and human serum albumin (HSA) to mannan nanogel were studied using intrinsic tryptophan fluorescence and circular dichroism spectroscopy. The mannan nanogel effect on blood coagulation and fibrillation of Alzheimer's disease-associated amyloid β peptide and hemodialysis-associated amyloidosis β2 microglobulin was evaluated using thrombin generation assay or thioflavin T fluorescence assay, respectively. The protein corona around mannan nanogel is formed through a slow process, is quite specific comprising apolipoproteins B-100, A-I and E and HSA, evolves over time, and the equilibrium is reached after hours to days. St...Continue Reading

References

Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·V ApostolopoulosI F McKenzie
Feb 1, 1996·European Journal of Immunology·A AvraméasP Midoux
Mar 20, 2002·Current Molecular Medicine·V Apostolopoulos, I F McKenzie
Nov 17, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Martin LundqvistBengt-Harald Jonsson
Dec 21, 2004·Nature Neuroscience·James P ClearyKaren H Ashe
Mar 23, 2006·Journal of the American Chemical Society·Paul RoachCarole C Perry
Jun 8, 2006·Annual Review of Biochemistry·Fabrizio Chiti, Christopher M Dobson
Aug 4, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Serena BaglioniMassimo Stefani
Feb 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tommy CedervallSara Linse
Feb 7, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Sotirios KoutsopoulosWillem Norde
May 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sara LinseKenneth A Dawson
Jun 15, 2007·International Journal of Pharmaceutics·Susumu NagayamaToshikiro Kimura
Jun 19, 2007·Advances in Colloid and Interface Science·Iseult LynchKenneth A Dawson
Jun 27, 2007·Angewandte Chemie·Tommy CedervallKenneth A Dawson
Sep 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Martin LundqvistKenneth A Dawson
Oct 29, 2008·Journal of the American Chemical Society·Celia Cabaleiro-LagoSara Linse
Jan 9, 2009·The Journal of Biological Chemistry·Cecilia OslakovicBjörn Dahlbäck
Apr 1, 2009·International Journal of Molecular Sciences·Li Fei, Sarah Perrett
May 15, 2009·The FEBS Journal·Erik HellstrandTommy Cedervall
Jun 30, 2009·Angewandte Chemie·Alexander V Kabanov, Serguei V Vinogradov
Sep 25, 2009·Journal of the Royal Society, Interface·Xiue JiangG Ulrich Nienhaus
Jan 12, 2010·Journal of Internal Medicine·G Oberdörster
Apr 2, 2010·Journal of the American Chemical Society·Dorota WalczykKenneth A Dawson
Jun 18, 2010·ACS Nano·Eudald CasalsVictor Puntes
Aug 17, 2010·Nature Nanotechnology·Xin-Rui XiaJim E Riviere
Nov 10, 2010·Biomaterials·Anna LesniakKenneth A Dawson
Feb 4, 2011·Journal of the American Chemical Society·Marco P MonopoliKenneth A Dawson
Apr 12, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Davide BrambillaKarine Andrieux
Jun 11, 2011·Journal of Colloid and Interface Science·Sílvia A FerreiraFrancisco M Gama
Jun 28, 2011·Biomaterials·Jennifer E GagnerRichard W Siegel
Aug 25, 2011·ACS Nano·Martin LundqvistKenneth Dawson
Aug 30, 2011·Advanced Drug Delivery Reviews·Ivana FenoglioFrancesco Turci
Oct 8, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Risto CukalevskiTommy Cedervall

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Citations

Jan 13, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Amal J SivaramM Sabitha
Sep 6, 2019·Expert Review of Vaccines·Luis Hernández-AdameSergio Rosales-Mendoza
Jul 1, 2020·Biopolymers·Chelladurai Karthikeyan BalavigneswaranNira Misra
Apr 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cindy GunawanRose Amal
Feb 14, 2018·Nanoscale·Stefán B GunnarssonTommy Cedervall
Jun 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Enrico MiceliMarcelo Calderón
Oct 17, 2017·Applied Microbiology and Biotechnology·Mario Cezar Rodrigues ManoGláucia Maria Pastore
Apr 18, 2017·PloS One·Martin LundqvistTommy Cedervall
Nov 11, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jana KubackovaOndrej Holas
Jan 29, 2021·International Journal of Biological Macromolecules·Rakesh Kumar MishraRehan Khan
May 29, 2021·Acta Biomaterialia·Hanmei LiQiang Peng

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