Biocompatibility of new calcium aluminate cement (EndoBinder)

Journal of Endodontics
Fabiano Gamero AguilarFernanda Carvalho Panzeri Pires-de-Souza

Abstract

The purpose of this study was to evaluate the biocompatibility of calcium aluminate cement (EndoBinder) in subcutaneous tissue of rats. Fifteen rats, weighing 300 g, were separated into 3 groups (n = 5) in accordance with the time of death (7, 21, 42 days). Two incisions were made in the dorsal subcutaneous tissue of each rat in which were implanted 2 polyethylene tubes filled with the test materials, EndoBinder (EB) and Grey MTA (GMTA). The external tube walls were considered the negative control group (CG). After 7, 21, and 42 days, animals were killed, obtaining 5 samples per group, at each time interval of analysis. From the morphologic and morphometric analyses by using a score of (0-3) (50, 100, and 400×), results showed absence of inflammatory reaction (0) for EB after 42 days. However, for GMTA, a slight inflammatory reaction (1) was observed after 42 days, which means the persistence of a chronic inflammatory process. When compared with CG, tissue reaction ranging from discrete (1-7 days) to absent (0-42 days) was observed. EndoBinder presented satisfactory tissue reaction; it was biocompatible when tested in subcutaneous tissue of rats.

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Citations

Apr 6, 2013·Journal of Applied Oral Science : Revista FOB·Clovis Monteiro BramanteAlexandre Silva Bramante
Jan 28, 2014·Journal of Endodontics·Lucas da Fonseca Roberti GarciaFernanda de Carvalho Panzeri Pires-de-Souza
May 21, 2013·Journal of Endodontics·Ivone Regina OliveiraVictor C Pandolfelli
Feb 28, 2015·Journal of Endodontics·Lucas da Fonseca Roberti GarciaCarlos Alberto de Souza Costa
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