Biocompatibility of poly(ethylene glycol) and poly(acrylic acid) interpenetrating network hydrogel by intrastromal implantation in rabbit cornea

Journal of Biomedical Materials Research. Part a
Luo Luo ZhengChristopher N Ta

Abstract

We evaluated the biocompatibility of a poly(ethylene glycol) and poly(acrylic acid) (PEG/PAA) interpenetrating network hydrogel designed for artificial cornea in a rabbit model. PEG/PAA hydrogel measuring 6 mm in diameter was implanted in the corneal stroma of twelve rabbits. Stromal flaps were created with a microkeratome. Randomly, six rabbits were assigned to bear the implant for 2 months, two rabbits for 6 months, two rabbits for 9 months, one rabbit for 12 months, and one rabbit for 16 months. Rabbits were evaluated monthly. After the assigned period, eyes were enucleated, and corneas were processed for histology and immunohistochemistry. There were clear corneas in three of six rabbits that had implantation of hydrogel for 2 months. In the six rabbits with implant for 6 months or longer, the corneas remained clear in four. There was a high rate of epithelial defect and corneal thinning in these six rabbits. One planned 9-month rabbit developed extrusion of implant at 4 months. The cornea remained clear in the 16-month rabbit but histology revealed epithelial in-growth. Intrastromal implantation of PEG/PAA resulted in a high rate of long-term complications.

References

Jan 1, 1988·International Ophthalmology Clinics·J C Barber
Sep 1, 1995·The British Journal of Ophthalmology·S PintucciS Caiazza
Oct 30, 1998·Biomaterials·J M Legeais, G Renard
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·N A PeppasH Ichikawa
Sep 12, 2000·Journal of Biomaterials Science. Polymer Edition·S VijayasekaranI J Constable
Nov 17, 2001·Chemical Reviews·K Y Lee, D J Mooney
Dec 18, 2001·Advanced Drug Delivery Reviews·Y Qiu, K Park
Jan 5, 2002·Advanced Drug Delivery Reviews·Allan S Hoffman
Sep 11, 2002·Biomaterials·Kytai Truong Nguyen, Jennifer L West
Jul 29, 2003·Cornea·Celia R Hicks, Geoffrey J Crawford
Sep 26, 2003·Cornea·Celia R HicksIan J Constable
Apr 2, 2004·Nature·Robert Langer, David A Tirrell
Apr 8, 2004·Clinical & Experimental Ophthalmology·Celia R HicksIan J Constable
Jul 15, 2005·Cornea·Celia R Hicks, Stephen Hamilton
Nov 17, 2006·Advanced Drug Delivery Reviews·J L BourgesF Behar-Cohen
Nov 30, 2006·Cornea·Celia R HicksMax Bulsara
Aug 28, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Basavaraj K NanjawadeA S Manjappa
Nov 29, 2007·Cornea·Kakarla V ChalamDeepak P Edward
Dec 14, 2007·Biomaterials·Wenguang LiuFengfu Li
Apr 22, 2008·Biotechnology Progress·David MyungCurtis W Frank
Oct 23, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S A HolakH Bleckmann
Sep 3, 2009·Cornea·Hall F ChewElisabeth J Cohen
Nov 27, 2009·American Journal of Ophthalmology·Jared D AmentClaes H Dohlman
Apr 20, 2010·Clinical & Experimental Ophthalmology·Ahmed GomaaChristopher Liu
Jul 9, 2010·International Ophthalmology Clinics·Michael A Klufas, Kathryn A Colby
Apr 20, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Laura HartmannCurtis W Frank
Jan 29, 2013·Journal of Materials Science. Materials in Medicine·Xiao Wei TanJodhbir S Mehta

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Citations

Jun 16, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Chilaluck C KonkankitJustin J Wilson
Nov 7, 2019·Journal of Biomaterials Applications·Carolina Oliver UrrutiaMiriam V Flores-Merino
Mar 20, 2019·The Analyst·Md ArifuzzamanJeffrey N Anker
Dec 24, 2019·Translational Vision Science & Technology·Aritz BidagurenNerea Garagorri
Jul 23, 2020·Tissue Engineering and Regenerative Medicine·S Sharareh MahdaviAli R Djalilian
Feb 3, 2021·International Journal of Molecular Sciences·Louis-Philippe GuérinSylvain L Guérin
Nov 10, 2020·Experimental Eye Research·Jorge L Alió Del BarrioJorge L Alió
Apr 23, 2021·Small·Sadjad KhosravimelalMazaher Gholipourmalekabadi
May 20, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Doron KamShlomo Magdassi
Aug 10, 2017·ACS Applied Materials & Interfaces·Sajid FazalDeepthy Menon

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