PMID: 15348747May 1, 1997Paper

Biocompatibility of solid poly (ortho ester)

Journal of Materials Science. Materials in Medicine
M EkholmR Suuronen

Abstract

In previous studies poly (ortho ester) (POE) has shown promise as a resorbable device, a hemostatic sealant and as a carrier for drugs in bone surgery. The aim of this study was to evaluate the tissue reactions of solid poly (ortho ester) implanted into both tibiae of 17 rabbits. One half of the rods were sterilized by gamma radiation and the other half by ethylene oxide. The follow-up times were from 1 week to 21 weeks, after which the animals were killed and the bony specimens examined histologically. The connective tissue samples were examined immunohistochemically in order to study the occurrences of two extracellular matrix glycoproteins, tenascin and fibronectin. The results showed that solid poly (ortho ester)s induce a moderate inflammatory reaction for 9 weeks. Tenascin and fibronectin were present in samples from 1 week up to 4 weeks. It was also found that gamma sterilized POE was resorbed at week 7 and ethylene oxide sterilized POE at week 13.

Citations

Dec 6, 2001·Advanced Drug Delivery Reviews·S EinmahlR Gurny
Aug 21, 2013·Journal of Materials Science. Materials in Medicine·J SuwanprateebP Rukskul

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