PMID: 2713618Apr 1, 1989

Biocompatibility of urinary catheters. Effect on complement activation

British Journal of Urology
P GarredB E Glahn

Abstract

The ability of 2 brands of urinary catheters to activate the complement system in vitro as a marker of biocompatibility was investigated. Pieces of a silicone/latex catheter and an all-silicone catheter were incubated in human serum. Complement activation was tested in 2 enzyme immunoassays, one evaluating C3 activation and the other the terminal complement complex (TCC) formation. The silicone/latex catheter caused considerably more complement activation in both assays than did the all-silicone one. The findings are in agreement with previous results of tissue toxicity tests. The methods presented may prove valuable for the practical purpose of testing the biocompatibility of urinary catheters.

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Apr 1, 1992·Acta Anaesthesiologica Scandinavica·M Salo
Dec 1, 1991·British Journal of Urology·G S RobertsonJ T Flynn
Apr 1, 1993·British Journal of Urology·S A HolmesH N Whitfield
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Related Concepts

Hemocompatible Materials
Hemolytic Complement
Complement Activation
Complement C3 precursor
Latex
Silicones
Foley Catheterization
Complement Membrane Attack Complex

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