Biocompatible 3D Matrix with Antimicrobial Properties

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Alberto IonAlina Maria Holban

Abstract

The aim of this study was to develop, characterize and assess the biological activity of a new regenerative 3D matrix with antimicrobial properties, based on collagen (COLL), hydroxyapatite (HAp), β-cyclodextrin (β-CD) and usnic acid (UA). The prepared 3D matrix was characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Microscopy (FT-IRM), Transmission Electron Microscopy (TEM), and X-ray Diffraction (XRD). In vitro qualitative and quantitative analyses performed on cultured diploid cells demonstrated that the 3D matrix is biocompatible, allowing the normal development and growth of MG-63 osteoblast-like cells and exhibited an antimicrobial effect, especially on the Staphylococcus aureus strain, explained by the particular higher inhibitory activity of usnic acid (UA) against Gram positive bacterial strains. Our data strongly recommend the obtained 3D matrix to be used as a successful alternative for the fabrication of three dimensional (3D) anti-infective regeneration matrix for bone tissue engineering.

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Citations

Aug 16, 2017·Bioinorganic Chemistry and Applications·Diogo José HorstRogério de Almeida Vieira

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Methods Mentioned

BETA
X-ray
Infrared Microscopy
Scanning Electron Microscopy
electron diffraction

Software Mentioned

Axio
OmincPicta
Vision

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