Biocompatible Chitosan-Functionalized Upconverting Nanocomposites

ACS Omega
Hau Van DuongThanh-Dinh Nguyen

Abstract

Simultaneous integration of photon emission and biocompatibility into nanoparticles is an interesting strategy to develop applications of advanced optical materials. In this work, we present the synthesis of biocompatible optical nanocomposites from the combination of near-infrared luminescent lanthanide nanoparticles and water-soluble chitosan. NaYF4:Yb,Er upconverting nanocrystal guests and water-soluble chitosan hosts are prepared and integrated together into biofunctional optical composites. The control of aqueous dissolution, gelation, assembly, and drying of NaYF4:Yb,Er nanocolloids and chitosan liquids allowed us to design novel optical structures of spongelike aerogels and beadlike microspheres. Well-defined shape and near-infrared response lead upconverting nanocrystals to serve as photon converters to couple with plasmonic gold (Au) nanoparticles. Biocompatible chitosan-stabilized Au/NaYF4:Yb,Er nanocomposites are prepared to show their potential use in biomedicine as we find them exhibiting a half-maximal effective concentration (EC50) of 0.58 mg mL-1 for chitosan-stabilized Au/NaYF4:Yb,Er nanorods versus 0.24 mg mL-1 for chitosan-stabilized NaYF4:Yb,Er after 24 h. As a result of their low cytotoxicity and upconverti...Continue Reading

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Citations

Apr 10, 2020·Angewandte Chemie·Satoru TakeshitaMatthias M Koebel
Feb 13, 2021·Biomedical Materials·Themis R KyriakidesWendy C Sheu
Sep 3, 2021·ACS Omega·Nechikkottil Sivadasan SumithaGopalakrishnanchettiar Sivakamiammal Sailaja

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Methods Mentioned

BETA
X-ray
Transmission electron microscopy
acetylation
optical microscopy
optical

Software Mentioned

OriginPro

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