Biocompatible Croconaine Aggregates with Strong 1.2-1.3 μm Absorption for NIR-IIa Photoacoustic Imaging in Vivo

ACS Applied Materials & Interfaces
Huanhuan LiuZijing Li

Abstract

Although photoacoustic imaging (PAI) in the second near-infrared (NIR-II) region (1.0-1.7 μm) is admired for deeper penetration and higher contrast, few organic NIR-II absorbers are available as exogenous contrast agents in vivo. A1094 belongs to the very few ∼1.1 μm absorbing croconaine dyes that have superior extinction coefficient and tend to form irregular aggregation. In this study, shape-controlled A1094@DSPE-PEG2000 micelles with a J-aggregate core with remarkable 1.2-1.3 μm absorption are fabricated as biocompatible organic agents. Excellent capabilities in photothermal conversion, photostability, and PAI are found in in vitro studies. In vivo PAI of inguinal lymph nodes and in situ glioma pre- and post-resection, all demonstrate high lymph/tumor-targeting efficiency. An ∼4.54 mm deep brain lesion is imaged at 1200 nm with minimized background and increased contrast compared to 970 nm. Overall, we achieved significant bathochromic shift of organic absorbers and expanded their PAI application to the long-wavelength end of the NIR-IIa region.

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Citations

Mar 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xue ZhangShiping Yang
May 5, 2021·Journal of Nanobiotechnology·Wei ZhaoLigong Lu
Jun 11, 2021·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Tao TangTaolei Sun
Jun 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuangying QiaoJingfeng Liu
Aug 14, 2020·Bioconjugate Chemistry·Shan LeiJing Lin
Sep 23, 2021·Reviews in the Neurosciences·Na XieXiaobo Wang

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