Biocompatible hydrogel nanocomposite with covalently embedded silver nanoparticles

Biomacromolecules
Clara García-AstrainNagore Gabilondo

Abstract

Bionanocomposite materials, combining the properties of biopolymers and nanostructured materials, are attracting interest of the wider scientific community due to their potential application in design of implants, drug delivery systems, and tissue design platforms. Herein, we report on the use of maleimide-coated silver nanoparticles (Ag NPs) as cocross-linkers for the preparation of a bionanocomposite gelatin based hydrogel. Diels-Alder cycloaddition of benzotriazole maleimide (BTM) functionalized Ag NPs and furan containing gelatin in combination with additional amide coupling resulted in stable and biocompatible hybrid nanocomposite. The storage moduli values for the hydrogel are nearly three times higher than that of control hydrogel without NPs indicating a stabilizing role of the covalently bound NPs. Finally, the swelling and drug release properties of the materials as well as the biocompatibility and toxicity tests indicate the biomedical potential of this type of material.

References

May 23, 2001·Advanced Drug Delivery Reviews·J Siepmann, N A Peppas
Mar 22, 2006·Chemical Communications : Chem Comm·David J LewisZoe Pikramenou
Oct 18, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Snezana MiljanićMladen Zinić
Oct 8, 2008·Macromolecular Bioscience·Janssen L VanderhooftGlenn D Prestwich
Feb 25, 2009·ACS Nano·P V AshaRaniSuresh Valiyaveettil
May 22, 2009·Biomacromolecules·Kristin SissonJohn F Rabolt
Jun 17, 2009·Macromolecular Bioscience·Vichayarat RattanaruengsrikulPitt Supaphol
Jan 1, 2010·The Journal of Physical Chemistry. B·Goutam PaluiArindam Banerjee
May 25, 2010·Acta Biomaterialia·Martín F DesimoneThibaud Coradin
Aug 24, 2010·Advanced Materials·Aleksander SkardalGlenn D Prestwich
Feb 15, 2011·Biomacromolecules·Chelsea M NimmoMolly S Shoichet
Apr 27, 2011·Macromolecular Rapid Communications·Huaping TanKacey G Marra
Feb 20, 2013·Biomacromolecules·Gulden Camci-UnalAli Khademhosseini
Mar 2, 2013·Journal of Nanoscience and Nanotechnology·Agnieszka Sobczak-KupiecBozena Tyliszczak
May 8, 2013·Journal of Biomedical Materials Research. Part a·Bandla ManjulaKonduru Mohana Raju
Nov 23, 2013·Biotechnology and Bioengineering·Akhilesh K GaharwarAli Khademhosseini
Feb 20, 2014·Macromolecular Bioscience·Marcelo A da SilvaCécile A Dreiss
Aug 2, 2014·ACS Applied Materials & Interfaces·James RamosKaushal Rege
Apr 1, 2014·Acta Pharmaceutica Sinica. B·Honey Priya JamesK R Anoop
Oct 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhou TangQigang Wang

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Citations

Apr 5, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Andrew T WoodVinoy Thomas
Jun 5, 2016·Carbohydrate Polymers·C García-AstrainN Gabilondo
Sep 3, 2016·International Journal of Molecular Sciences·Panoraia I SiafakaDimitrios N Bikiaris
Jun 2, 2017·ACS Applied Materials & Interfaces·Shuai ChenLidong Li
Feb 14, 2019·Bioengineering·Hui-Li TanJanarthanan Pushpamalar
Aug 30, 2019·Biotechnology Journal·Henriette M C AzeredoLuiz Henrique C Mattoso
Nov 7, 2019·Soft Matter·Pritam ChoudhuryPrasanta Kumar Das
Oct 11, 2017·Polymers·Mehmet Arslan, Mehmet Atilla Tasdelen
Feb 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dong ZhangJie Zheng
Mar 5, 2021·International Journal of Biological Macromolecules·Hossein GhasemzadehSamira Hassanpour
Sep 22, 2018·Journal of Agricultural and Food Chemistry·Xiaoliang QiWei Dong
May 6, 2017·ACS Applied Materials & Interfaces·Yunki LeeKi Dong Park
Aug 26, 2020·ACS Applied Materials & Interfaces·Hanif HaidariKrasimir Vasilev
Sep 24, 2021·Macromolecular Bioscience·Birgit StubbePeter Dubruel
May 29, 2020·Ecotoxicology and Environmental Safety·Mariana Alves Leite DutraRosangela de Carvalho Balaban

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