Abstract
Mn(2+)-doped carbonated hydroxyapatite (Mn-CHA) thin films were obtained by pulsed laser deposition on Ti substrates. The results of the performed complementary diagnostic techniques, X-ray diffraction, infrared spectroscopy, X-ray photoelectron spectroscopy, and energy dispersive X-ray spectroscopy investigations indicate that the films are crystalline with a Ca/P ratio of about 1.64-1.66. The optimum conditions, when nearly stoichiometric crystalline thin films were deposited, were found to be 10 Pa oxygen pressure, 400 degrees C substrate temperature, and postdeposition heat treatment in water vapors at the same substrate temperature. The films were seeded with L929 fibroblast and hFOB1.19 osteoblast cells and subjected to in vitro tests. Both fibroblast and osteoblast cells have a good adherence on the Mn-CHA film and on the Ti or polystyrene references. Proliferation and viability tests showed that osteoblast cells growth on Mn-CHA-coated Ti was enhanced as compared to uncoated pure Ti surfaces. Caspase-1 activity was not affected significantly by the material, showing that Mn-CHA does not induce apoptosis of cultured cells. These results demonstrate that Mn-CHA films on Ti should provoke a faster osteointegration of the c...Continue Reading
References
Jan 1, 1984·Caries Research·J D FeatherstoneR Z LeGeros
Jun 1, 1994·Biomaterials·R K SinghB M Moudgil
Oct 30, 1998·Biomaterials·L ClèriesJ L Morenza
Jan 7, 2000·Experimental Cell Research·A ArmulikS Johansson
Feb 24, 2001·Biomaterials·M D BallS M Howdle
Jun 16, 2001·Journal of Biomedical Materials Research·D PerizzoloD M Brunette
May 30, 2002·Biomaterials·D TadicM Epple
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·H KurzwegT Troczynski
Jul 1, 1997·Journal of Materials Science. Materials in Medicine·F Z CuiQ L Feng
Apr 1, 1997·Journal of Materials Science. Materials in Medicine·E ChangC Y Yang
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·F J García-SanzM Pérez-Amor
Jan 1, 2001·Journal of Research of the National Institute of Standards and Technology·M Mathew, S Takagi
Citations
Jun 29, 2007·Journal of Materials Science. Materials in Medicine·Y HashimotoM Nakamura
Mar 28, 2007·Journal of Materials Science. Materials in Medicine·Y HashimotoM Nakamura
May 21, 2013·Journal of Materials Science. Materials in Medicine·Yong HuangXiaofeng Pang
Mar 25, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Marta MiolaEnrica Vernè
Dec 9, 2004·Biomaterials·A BigiP Torricelli
Nov 6, 2007·Journal of Inorganic Biochemistry·I MayerI Popov
Mar 4, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Gabriela GrazianiMaurilio Marcacci
Feb 6, 2017·Colloids and Surfaces. B, Biointerfaces·Le YuXuanyong Liu
Nov 5, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·S LalaS K Pradhan
Feb 22, 2013·Journal of Biomedical Materials Research. Part a·M M MotocE Gyorgy
Feb 18, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Daniel Arcos, María Vallet-Regí
Sep 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Le YuXuanyong Liu
Apr 2, 2010·ACS Applied Materials & Interfaces·Julietta V RauSergey M Barinov
Apr 22, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ming WangShiping Yang