Biocompatible Mn2+-doped carbonated hydroxyapatite thin films grown by pulsed laser deposition

Journal of Biomedical Materials Research. Part a
E GyörgyJ Werckman

Abstract

Mn(2+)-doped carbonated hydroxyapatite (Mn-CHA) thin films were obtained by pulsed laser deposition on Ti substrates. The results of the performed complementary diagnostic techniques, X-ray diffraction, infrared spectroscopy, X-ray photoelectron spectroscopy, and energy dispersive X-ray spectroscopy investigations indicate that the films are crystalline with a Ca/P ratio of about 1.64-1.66. The optimum conditions, when nearly stoichiometric crystalline thin films were deposited, were found to be 10 Pa oxygen pressure, 400 degrees C substrate temperature, and postdeposition heat treatment in water vapors at the same substrate temperature. The films were seeded with L929 fibroblast and hFOB1.19 osteoblast cells and subjected to in vitro tests. Both fibroblast and osteoblast cells have a good adherence on the Mn-CHA film and on the Ti or polystyrene references. Proliferation and viability tests showed that osteoblast cells growth on Mn-CHA-coated Ti was enhanced as compared to uncoated pure Ti surfaces. Caspase-1 activity was not affected significantly by the material, showing that Mn-CHA does not induce apoptosis of cultured cells. These results demonstrate that Mn-CHA films on Ti should provoke a faster osteointegration of the c...Continue Reading

References

Jan 1, 1984·Caries Research·J D FeatherstoneR Z LeGeros
Jun 1, 1994·Biomaterials·R K SinghB M Moudgil
May 30, 2002·Biomaterials·D TadicM Epple
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·H KurzwegT Troczynski
Jul 1, 1997·Journal of Materials Science. Materials in Medicine·F Z CuiQ L Feng
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·F J García-SanzM Pérez-Amor
Jan 1, 2001·Journal of Research of the National Institute of Standards and Technology·M Mathew, S Takagi

❮ Previous
Next ❯

Citations

Jun 29, 2007·Journal of Materials Science. Materials in Medicine·Y HashimotoM Nakamura
Mar 28, 2007·Journal of Materials Science. Materials in Medicine·Y HashimotoM Nakamura
May 21, 2013·Journal of Materials Science. Materials in Medicine·Yong HuangXiaofeng Pang
Mar 25, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Marta MiolaEnrica Vernè
Mar 4, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Gabriela GrazianiMaurilio Marcacci
Feb 6, 2017·Colloids and Surfaces. B, Biointerfaces·Le YuXuanyong Liu
Feb 22, 2013·Journal of Biomedical Materials Research. Part a·M M MotocE Gyorgy
Feb 18, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Daniel Arcos, María Vallet-Regí
Sep 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Le YuXuanyong Liu
Apr 2, 2010·ACS Applied Materials & Interfaces·Julietta V RauSergey M Barinov
Apr 22, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ming WangShiping Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis