Biocompatible organic-inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition

Beilstein Journal of Nanotechnology
Leva MomtaziOla Nilsen

Abstract

We have constructed thin films of organic-inorganic hybrid character by combining titanium tetra-isopropoxide (TTIP) and the nucleobases thymine, uracil or adenine using the molecular layer deposition (MLD) approach. Such materials have potential as bioactive coatings, and the bioactivity of these films is described in our recent work [Momtazi, L.; Dartt, D. A.; Nilsen, O.; Eidet, J. R. J. Biomed. Mater. Res., Part A2018,106, 3090-3098. doi:10.1002/jbm.a.36499]. The growth was followed by in situ quartz crystal microbalance (QCM) measurements and all systems exhibited atomic layer deposition (ALD) type of growth. The adenine system has an ALD temperature window between 250 and 300 °C, while an overall reduction in growth rate with increasing temperature was observed for the uracil and thymine systems. The bonding modes of the films have been further characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and X-ray diffraction, confirming the hybrid nature of the as-deposited films with an amorphous structure where partial inclusion of the TTIP molecule occurs during growth. The films are highly hydrophilic, while the nucleobases do leach in water providing an amorphous structure mainly of TiO2...Continue Reading

References

Apr 13, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Paul J Dyson, Gianni Sava
Dec 19, 2007·Journal of Biomedical Materials Research. Part a·Dudley S FinchRoop L Mahajan
Aug 22, 2008·The Journal of Chemical Physics·Sylwia PtasińskaLéon Sanche
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Sep 9, 2018·Journal of Biomedical Materials Research. Part a·Leva MomtaziJon Roger Eidet

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Citations

May 1, 2020·Nanotechnology·Karina AshurbekovaMato Knez

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Methods Mentioned

BETA
X-ray
XRD
atomic force microscopy
AFM
quartz crystal microbalance

Software Mentioned

SPM
DROP
Gwyddion

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