Biocompatible PEGylated gold nanorods as colored contrast agents for targeted in vivo cancer applications

Nanotechnology
Atcha KopwitthayaParas N Prasad

Abstract

In this contribution, we report the use of a PEGylated gold nanorods formulation as a colored dye for tumor labeling in vivo. We have demonstrated that the nanorod-targeted tumor site can be easily differentiated from the background tissues by the 'naked eye' without the need of sophisticated imaging instruments. In addition to tumor labeling, we have also performed in vivo toxicity and biodistribution studies of PEGylated gold nanorods in vivo by using BALB/c mice as the model. In vivo toxicity studies indicated no mortality or adverse effects or weight changes in BALB/c mice treated with PEGylated gold nanorods. This finding will provide useful guidelines in the future development of diagnostic probes for cancer diagnosis, optically guided tumor surgery, and lymph node mapping applications.

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Citations

May 31, 2012·Drug Delivery·Ravikumar AalinkeelStanley A Schwartz
Jan 23, 2016·Chemical Reviews·Guanying ChenParas N Prasad
Jun 12, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Tymish Y OhulchanskyyParas N Prasad
Nov 6, 2014·ACS Applied Materials & Interfaces·Jing YuYan-ping Shi
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Maria Elena GallinaDaniel S Elson
Aug 30, 2014·Contrast Media & Molecular Imaging·Connor A WathenRaghuraman Kannan
Sep 28, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Folarin ErogbogboParas N Prasad
Aug 16, 2016·Carbohydrate Polymers·Heloise Ribeiro de BarrosIzabel C Riegel-Vidotti
May 21, 2020·Scientific Reports·Yongxiu YangXiaolei Liang
Sep 5, 2013·Chemical Communications : Chem Comm·Maixian LiuParas N Prasad
Sep 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Francesca TatiniRoberto Pini

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