Biocompatible properties of nano-drug carriers using TiO2 -Au embedded on multiwall carbon nanotubes for targeted drug delivery

Materials Science & Engineering. C, Materials for Biological Applications
Viswanathan KarthikaGiovanni Benelli

Abstract

Nanomaterial-based drug carriers have become a hot spot of research at the interface of nanotechnology and biomedicine because they allow efficient loading, targeted delivery, controlled release of drugs, and therefore are promising for biomedical applications. The current study made an attempt to decorate the multiwalled carbon nanotubes (MWCNT) with titanium dioxide‑gold nanoparticles in order to enhance the biocompatibility for doxorubicin (DOX) delivery. The successful synthesis of nano drug carrier (NDC) was confirmed by XRD, XPS and UV-Visible spectroscopy. FESEM and TEM revealed that the morphology of NDC can be controlled by manipulating the reaction duration, MWCNT concentration and TiO2-Au source concentration. Results showed that TiO2 and Au nanoparticles were well coated on MWCNT. NDC had finely tuned biocompatible properties, as elucidated by hemolytic and antimicrobial assays. NDC also showed a high antioxidant potential, 80.7% expressed as ascorbic acid equivalents. Commercial DOX drug was utilized to treat A549 and MCF7 cancer cell lines showing improved efficiency by formulating it with NDC, which selectively delivered at the pH 5.5 with drug loading capacity of 0.45 mg/mL. The drug releasing capacity achieved ...Continue Reading

Citations

Jul 18, 2020·Organic & Biomolecular Chemistry·Andrzej S SkwareckiMaria J Milewska
Jul 7, 2018·Nanomaterials·Neelika Roy ChowdhuryKrasimir Vasilev
Mar 1, 2019·International Journal of Molecular Sciences·Safia NazJinghua Chen
Dec 12, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Danushika C ManatungaK M Nalin de Silva
Nov 5, 2020·Scientific Reports·Viswanathan KarthikaMarimuthu Govindarajan
Aug 25, 2020·ACS Medicinal Chemistry Letters·Weiwei MaGuisheng Zhang

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