Biocompatible silk/calcium silicate/sodium alginate composite scaffolds for bone tissue engineering

Carbohydrate Polymers
Ao ZhengXinquan Jiang

Abstract

Scaffolds are crucial for bone tissue engineering since their compositions and properties could significantly affect the seeded cells' behavior. In this study, we developed an interpenetrating network hydrogel by utilizing Ca2+ from calcium silicate (CS) to simultaneously crosslink silk fibroin (SF) and sodium alginate (SA). Afterwards, the hydrogels were lyophilized to obtain scaffolds and systematically evaluated by physical characterizations, in vitro cytocompatibility and alkaline phosphatase (ALP) assay. We found that CS inside the porous structure of SF/CS/SA scaffolds could remarkably enhance hydrophilicity, degradation, compression resistance, bioactivity and pH of SF/CS/SA scaffolds. Scaffolds with CS concentrations of 25% and 12% (25/CS and 12/CS) could dominantly stimulate proliferation of bone marrow stromal cells (BMSCs). Besides, BMSCs cultured with 25/CS and 12/CS scaffolds showed high ALP activity, respectively. Consequently, this study suggested SF/CS/SA scaffolds possess potential in non-loading bone tissue engineering application.

Citations

Jan 29, 2019·Biomaterials Science·Xiao-Yuan PengZhen-Hong Zhu
Aug 1, 2019·Biomaterials Science·Anastasiia KashirinaJinsong Leng
Jan 24, 2020·Journal of Biomaterials Science. Polymer Edition·Mengjie XuDi Huang
Jan 10, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ji JiXuerong Fan
Mar 7, 2021·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Bei-Yong ShenQi Zhou
May 7, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jasmina StojkovskaDjordje N Veljovic
Jun 11, 2021·ACS Applied Materials & Interfaces·Lan ZhangVincent M Rotello
Jun 13, 2021·Macromolecular Bioscience·Xiaohan SuJun Wu
Jun 13, 2021·Macromolecular Bioscience·Zhaozhao DingQiang Lu
Nov 11, 2019·ACS Biomaterials Science & Engineering·You ZhouYapei Wang
Aug 27, 2021·Macromolecular Rapid Communications·Xingchen LiQuan Lin

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